Neuroprotective Potential and Chemical Profile of Alternatively Cultivated Ganoderma lucidum Basidiocarps
Само за регистроване кориснике
2018
Аутори
Ćilerdžić, JasminaSofrenić, Ivana V.
Tešević, Vele
Brčeski, Ilija
Duletić-Laušević, Sonja
Vukojević, Jelena
Stajić, Mirjana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Various neurodegenerative diseases are the main challenges to the modern medicine and there is a great need for novel, natural, neuroprotective agents. Ganoderma lucidum is a well-known medicinal mushroom, which health benefits have been confirmed by numerous studies. As demand for its basidiocarps is increased and traditional cultivation on hardwoods is not environmentally friendly and economically justified, finding of alternative substrates is necessary. The aim of the study was to assess the effect of alternative cultivation substrates on the chemical profile of G.lucidum basidiocarps and their capacity to inhibit acetylcholinesterase and tyrosinase, which higher activity is directly associated with neurodegenerative processes. Extracts of basidiocarps cultivated on alternative substrates, especially on clear wheat straw, showed significantly higher inhibition capacities than extracts of commercially-grown ones. These extracts were considerably different chemically from commercial ...basidiocarps extracts and even nine new compounds were isolated from them. Our results suggest that cultivation substrate greatly affect the chemical profile and neuroprotective capacity of obtained basidiocarps and wheat straw is a promising cultivation substrate.
Кључне речи:
biological activity / chemical profile / cultivation substrates / enzymes / Ganoderma lucidumИзвор:
Chemistry and Biodiversity, 2018, 15, 5Издавач:
- Wiley-V C H Verlag Gmbh, Weinheim
Финансирање / пројекти:
- Биоактивни природни производи самониклих, гајених и јестивих биљака: одређивање структура и активности (RS-MESTD-Basic Research (BR or ON)-172053)
- Карактеризација и примена метаболита гљива и утврђивање потенцијала нових биофунгицида (RS-MESTD-Basic Research (BR or ON)-173032)
DOI: 10.1002/cbdv.201800036
ISSN: 1612-1872
PubMed: 29624845
WoS: 000434072600008
Scopus: 2-s2.0-85046026699
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Ćilerdžić, Jasmina AU - Sofrenić, Ivana V. AU - Tešević, Vele AU - Brčeski, Ilija AU - Duletić-Laušević, Sonja AU - Vukojević, Jelena AU - Stajić, Mirjana PY - 2018 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2153 AB - Various neurodegenerative diseases are the main challenges to the modern medicine and there is a great need for novel, natural, neuroprotective agents. Ganoderma lucidum is a well-known medicinal mushroom, which health benefits have been confirmed by numerous studies. As demand for its basidiocarps is increased and traditional cultivation on hardwoods is not environmentally friendly and economically justified, finding of alternative substrates is necessary. The aim of the study was to assess the effect of alternative cultivation substrates on the chemical profile of G.lucidum basidiocarps and their capacity to inhibit acetylcholinesterase and tyrosinase, which higher activity is directly associated with neurodegenerative processes. Extracts of basidiocarps cultivated on alternative substrates, especially on clear wheat straw, showed significantly higher inhibition capacities than extracts of commercially-grown ones. These extracts were considerably different chemically from commercial basidiocarps extracts and even nine new compounds were isolated from them. Our results suggest that cultivation substrate greatly affect the chemical profile and neuroprotective capacity of obtained basidiocarps and wheat straw is a promising cultivation substrate. PB - Wiley-V C H Verlag Gmbh, Weinheim T2 - Chemistry and Biodiversity T1 - Neuroprotective Potential and Chemical Profile of Alternatively Cultivated Ganoderma lucidum Basidiocarps VL - 15 IS - 5 DO - 10.1002/cbdv.201800036 ER -
@article{ author = "Ćilerdžić, Jasmina and Sofrenić, Ivana V. and Tešević, Vele and Brčeski, Ilija and Duletić-Laušević, Sonja and Vukojević, Jelena and Stajić, Mirjana", year = "2018", abstract = "Various neurodegenerative diseases are the main challenges to the modern medicine and there is a great need for novel, natural, neuroprotective agents. Ganoderma lucidum is a well-known medicinal mushroom, which health benefits have been confirmed by numerous studies. As demand for its basidiocarps is increased and traditional cultivation on hardwoods is not environmentally friendly and economically justified, finding of alternative substrates is necessary. The aim of the study was to assess the effect of alternative cultivation substrates on the chemical profile of G.lucidum basidiocarps and their capacity to inhibit acetylcholinesterase and tyrosinase, which higher activity is directly associated with neurodegenerative processes. Extracts of basidiocarps cultivated on alternative substrates, especially on clear wheat straw, showed significantly higher inhibition capacities than extracts of commercially-grown ones. These extracts were considerably different chemically from commercial basidiocarps extracts and even nine new compounds were isolated from them. Our results suggest that cultivation substrate greatly affect the chemical profile and neuroprotective capacity of obtained basidiocarps and wheat straw is a promising cultivation substrate.", publisher = "Wiley-V C H Verlag Gmbh, Weinheim", journal = "Chemistry and Biodiversity", title = "Neuroprotective Potential and Chemical Profile of Alternatively Cultivated Ganoderma lucidum Basidiocarps", volume = "15", number = "5", doi = "10.1002/cbdv.201800036" }
Ćilerdžić, J., Sofrenić, I. V., Tešević, V., Brčeski, I., Duletić-Laušević, S., Vukojević, J.,& Stajić, M.. (2018). Neuroprotective Potential and Chemical Profile of Alternatively Cultivated Ganoderma lucidum Basidiocarps. in Chemistry and Biodiversity Wiley-V C H Verlag Gmbh, Weinheim., 15(5). https://doi.org/10.1002/cbdv.201800036
Ćilerdžić J, Sofrenić IV, Tešević V, Brčeski I, Duletić-Laušević S, Vukojević J, Stajić M. Neuroprotective Potential and Chemical Profile of Alternatively Cultivated Ganoderma lucidum Basidiocarps. in Chemistry and Biodiversity. 2018;15(5). doi:10.1002/cbdv.201800036 .
Ćilerdžić, Jasmina, Sofrenić, Ivana V., Tešević, Vele, Brčeski, Ilija, Duletić-Laušević, Sonja, Vukojević, Jelena, Stajić, Mirjana, "Neuroprotective Potential and Chemical Profile of Alternatively Cultivated Ganoderma lucidum Basidiocarps" in Chemistry and Biodiversity, 15, no. 5 (2018), https://doi.org/10.1002/cbdv.201800036 . .