Statistical dependence of protein secondary structure on amino acid bigrams [Statistička zavisnost sekundarne strukture proteina od frekvencije bigrama aminokiselina]

Abstract

The statistical dependence of protein secondary structure on amino acid bigram frequencies was studied. Proteins in the PDBSELECT subset of the Protein Data Bank database were investigated. Protein secondary structures were determined using DSSP software. The conditional probabilities of protein secondary structures were calculated and presented. The results on bigrams show the frequencies of all the possible bigrams in all secondary structure types. These results elucidate some factors important for the prediction of the secondary structures of proteins based on the amino acid sequence. © 2017, CI and CEQ. All rights reserved.

U radu je opisana statistička zavisnost sekundarne strukture proteina od bigrama aminokiselina. Istraživanje je urađeno na proteinima koji se nalaze u podskupu PDBSELECT baze podataka o proteinima Protein Data Bank (PDB). Sekundarne strukture proteina su određene primenom programa DSSP. Izračunate su i prikazane uslovne verovatnoće pojavljivanja različitih sekundarnih struktura. Rezultati za bigrame su prikazani za sve tipove sekundarnih struktura. Rezultati ukazuju na faktore koji su značajni za predviđanje sekundarne strukture proteina koje je zasnovano na redosledu aminokiselina u proteinu.