In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases
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AuthorsPetrović, Zorica D.
Trifunović, Snežana S.
Petrović, Vladimir P.
Article (Published version)
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N-Salicylidene and N-vanillidene anil Schiff bases SB-1-5 were evaluated for their iron-coordinating properties. For this purpose, reactions with Fe(III) chloride were performed. The obtained results showed that salicylaldehyde bases SB-1 and SB-2 are the best coordinating ligands among the investigated SBs. The corresponding complexes are obtained in good yield and investigated using UV-Vis spectrophotometry and IR spectroscopy. The inhibitory potential of SB-1-5 against iron-containing enzyme lipoxygenase (LOX) was also tested. Salicylidene bases exerted better activity then vanilliden. The cytotoxic in vitro activities against human breast carcinoma MDA-MB-231 and human colon carcinoma HCT-116 cell lines were determined. Based on these results, SB-1 and SB-2 can be considered as interesting compounds for further in vivo investigations.
Keywords:Anti-LOX activity / Cytotoxic activity / Iron-coordinating properties / UV-Vis spectrophotometry / IR spectroscopy
Source:Chemical Papers = Chemicke Zvesti, 2018, 72, 9, 2171-2180
- Springer International Publishing Ag, Cham
- Synthesis, modeling, physicochemical and biological properties of organic compounds and related metal complexes (RS-172016)
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3209