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In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases
N-Salicylidene and N-vanillidene anil Schiff bases SB-1-5 were evaluated for their iron-coordinating properties. For this purpose, reactions with Fe(III) chloride were performed. The obtained results showed that salicylaldehyde bases SB-1 and SB-2 are the best coordinating ligands among the investigated SBs. The corresponding complexes are obtained in good yield and investigated using UV-Vis spectrophotometry and IR spectroscopy. The inhibitory potential of SB-1-5 against iron-containing enzyme lipoxygenase (LOX) was also tested. Salicylidene bases exerted better activity then vanilliden. The cytotoxic in vitro activities against human breast carcinoma MDA-MB-231 and human colon carcinoma HCT-116 cell lines were determined. Based on these results, SB-1 and SB-2 can be considered as interesting compounds for further in vivo investigations.
TY - JOUR
AU - Petrović, Zorica D.
AU - Đorović, Jelena
AU - Simijonović, Dušica
AU - Trifunović, Snežana S.
AU - Petrović, Vladimir P.
PY - 2018
UR - https://cherry.chem.bg.ac.rs/handle/123456789/2190
AB - N-Salicylidene and N-vanillidene anil Schiff bases SB-1-5 were evaluated for their iron-coordinating properties. For this purpose, reactions with Fe(III) chloride were performed. The obtained results showed that salicylaldehyde bases SB-1 and SB-2 are the best coordinating ligands among the investigated SBs. The corresponding complexes are obtained in good yield and investigated using UV-Vis spectrophotometry and IR spectroscopy. The inhibitory potential of SB-1-5 against iron-containing enzyme lipoxygenase (LOX) was also tested. Salicylidene bases exerted better activity then vanilliden. The cytotoxic in vitro activities against human breast carcinoma MDA-MB-231 and human colon carcinoma HCT-116 cell lines were determined. Based on these results, SB-1 and SB-2 can be considered as interesting compounds for further in vivo investigations.
PB - Springer International Publishing Ag, Cham
T2 - Chemical Papers = Chemicke Zvesti
T1 - In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases
VL - 72
IS - 9
SP - 2171
EP - 2180
DO - 10.1007/s11696-018-0419-5
ER -
@article{
author = "Petrović, Zorica D. and Đorović, Jelena and Simijonović, Dušica and Trifunović, Snežana S. and Petrović, Vladimir P.",
year = "2018",
abstract = "N-Salicylidene and N-vanillidene anil Schiff bases SB-1-5 were evaluated for their iron-coordinating properties. For this purpose, reactions with Fe(III) chloride were performed. The obtained results showed that salicylaldehyde bases SB-1 and SB-2 are the best coordinating ligands among the investigated SBs. The corresponding complexes are obtained in good yield and investigated using UV-Vis spectrophotometry and IR spectroscopy. The inhibitory potential of SB-1-5 against iron-containing enzyme lipoxygenase (LOX) was also tested. Salicylidene bases exerted better activity then vanilliden. The cytotoxic in vitro activities against human breast carcinoma MDA-MB-231 and human colon carcinoma HCT-116 cell lines were determined. Based on these results, SB-1 and SB-2 can be considered as interesting compounds for further in vivo investigations.",
publisher = "Springer International Publishing Ag, Cham",
journal = "Chemical Papers = Chemicke Zvesti",
title = "In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases",
volume = "72",
number = "9",
pages = "2171-2180",
doi = "10.1007/s11696-018-0419-5"
}
Petrović, Z. D., Đorović, J., Simijonović, D., Trifunović, S. S.,& Petrović, V. P.. (2018). In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases. in Chemical Papers = Chemicke Zvesti
Springer International Publishing Ag, Cham., 72(9), 2171-2180.
https://doi.org/10.1007/s11696-018-0419-5
Petrović ZD, Đorović J, Simijonović D, Trifunović SS, Petrović VP. In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases. in Chemical Papers = Chemicke Zvesti. 2018;72(9):2171-2180.
doi:10.1007/s11696-018-0419-5 .
Petrović, Zorica D., Đorović, Jelena, Simijonović, Dušica, Trifunović, Snežana S., Petrović, Vladimir P., "In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases" in Chemical Papers = Chemicke Zvesti, 72, no. 9 (2018):2171-2180,
https://doi.org/10.1007/s11696-018-0419-5 . .
