In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases
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2018
Authors
Petrović, Zorica D.Đorović, Jelena
Simijonović, Dušica
Trifunović, Snežana S.
Petrović, Vladimir P.
Article (Published version)
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N-Salicylidene and N-vanillidene anil Schiff bases SB-1-5 were evaluated for their iron-coordinating properties. For this purpose, reactions with Fe(III) chloride were performed. The obtained results showed that salicylaldehyde bases SB-1 and SB-2 are the best coordinating ligands among the investigated SBs. The corresponding complexes are obtained in good yield and investigated using UV-Vis spectrophotometry and IR spectroscopy. The inhibitory potential of SB-1-5 against iron-containing enzyme lipoxygenase (LOX) was also tested. Salicylidene bases exerted better activity then vanilliden. The cytotoxic in vitro activities against human breast carcinoma MDA-MB-231 and human colon carcinoma HCT-116 cell lines were determined. Based on these results, SB-1 and SB-2 can be considered as interesting compounds for further in vivo investigations.
Keywords:
Anti-LOX activity / Cytotoxic activity / Iron-coordinating properties / UV-Vis spectrophotometry / IR spectroscopySource:
Chemical Papers = Chemicke Zvesti, 2018, 72, 9, 2171-2180Publisher:
- Springer International Publishing Ag, Cham
Funding / projects:
Note:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3209
DOI: 10.1007/s11696-018-0419-5
ISSN: 0366-6352
WoS: 000440149500006
Scopus: 2-s2.0-85050726703
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Petrović, Zorica D. AU - Đorović, Jelena AU - Simijonović, Dušica AU - Trifunović, Snežana S. AU - Petrović, Vladimir P. PY - 2018 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2190 AB - N-Salicylidene and N-vanillidene anil Schiff bases SB-1-5 were evaluated for their iron-coordinating properties. For this purpose, reactions with Fe(III) chloride were performed. The obtained results showed that salicylaldehyde bases SB-1 and SB-2 are the best coordinating ligands among the investigated SBs. The corresponding complexes are obtained in good yield and investigated using UV-Vis spectrophotometry and IR spectroscopy. The inhibitory potential of SB-1-5 against iron-containing enzyme lipoxygenase (LOX) was also tested. Salicylidene bases exerted better activity then vanilliden. The cytotoxic in vitro activities against human breast carcinoma MDA-MB-231 and human colon carcinoma HCT-116 cell lines were determined. Based on these results, SB-1 and SB-2 can be considered as interesting compounds for further in vivo investigations. PB - Springer International Publishing Ag, Cham T2 - Chemical Papers = Chemicke Zvesti T1 - In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases VL - 72 IS - 9 SP - 2171 EP - 2180 DO - 10.1007/s11696-018-0419-5 ER -
@article{ author = "Petrović, Zorica D. and Đorović, Jelena and Simijonović, Dušica and Trifunović, Snežana S. and Petrović, Vladimir P.", year = "2018", abstract = "N-Salicylidene and N-vanillidene anil Schiff bases SB-1-5 were evaluated for their iron-coordinating properties. For this purpose, reactions with Fe(III) chloride were performed. The obtained results showed that salicylaldehyde bases SB-1 and SB-2 are the best coordinating ligands among the investigated SBs. The corresponding complexes are obtained in good yield and investigated using UV-Vis spectrophotometry and IR spectroscopy. The inhibitory potential of SB-1-5 against iron-containing enzyme lipoxygenase (LOX) was also tested. Salicylidene bases exerted better activity then vanilliden. The cytotoxic in vitro activities against human breast carcinoma MDA-MB-231 and human colon carcinoma HCT-116 cell lines were determined. Based on these results, SB-1 and SB-2 can be considered as interesting compounds for further in vivo investigations.", publisher = "Springer International Publishing Ag, Cham", journal = "Chemical Papers = Chemicke Zvesti", title = "In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases", volume = "72", number = "9", pages = "2171-2180", doi = "10.1007/s11696-018-0419-5" }
Petrović, Z. D., Đorović, J., Simijonović, D., Trifunović, S. S.,& Petrović, V. P.. (2018). In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases. in Chemical Papers = Chemicke Zvesti Springer International Publishing Ag, Cham., 72(9), 2171-2180. https://doi.org/10.1007/s11696-018-0419-5
Petrović ZD, Đorović J, Simijonović D, Trifunović SS, Petrović VP. In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases. in Chemical Papers = Chemicke Zvesti. 2018;72(9):2171-2180. doi:10.1007/s11696-018-0419-5 .
Petrović, Zorica D., Đorović, Jelena, Simijonović, Dušica, Trifunović, Snežana S., Petrović, Vladimir P., "In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases" in Chemical Papers = Chemicke Zvesti, 72, no. 9 (2018):2171-2180, https://doi.org/10.1007/s11696-018-0419-5 . .