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In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases
dc.creator | Petrović, Zorica D. | |
dc.creator | Đorović, Jelena | |
dc.creator | Simijonović, Dušica | |
dc.creator | Trifunović, Snežana S. | |
dc.creator | Petrović, Vladimir P. | |
dc.date.accessioned | 2018-11-22T00:44:51Z | |
dc.date.available | 2018-11-22T00:44:51Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0366-6352 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/2190 | |
dc.description.abstract | N-Salicylidene and N-vanillidene anil Schiff bases SB-1-5 were evaluated for their iron-coordinating properties. For this purpose, reactions with Fe(III) chloride were performed. The obtained results showed that salicylaldehyde bases SB-1 and SB-2 are the best coordinating ligands among the investigated SBs. The corresponding complexes are obtained in good yield and investigated using UV-Vis spectrophotometry and IR spectroscopy. The inhibitory potential of SB-1-5 against iron-containing enzyme lipoxygenase (LOX) was also tested. Salicylidene bases exerted better activity then vanilliden. The cytotoxic in vitro activities against human breast carcinoma MDA-MB-231 and human colon carcinoma HCT-116 cell lines were determined. Based on these results, SB-1 and SB-2 can be considered as interesting compounds for further in vivo investigations. | en |
dc.publisher | Springer International Publishing Ag, Cham | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172016/RS// | |
dc.rights | restrictedAccess | |
dc.source | Chemical Papers = Chemicke Zvesti | |
dc.subject | Anti-LOX activity | en |
dc.subject | Cytotoxic activity | en |
dc.subject | Iron-coordinating properties | en |
dc.subject | UV-Vis spectrophotometry | en |
dc.subject | IR spectroscopy | en |
dc.title | In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Трифуновић, Снежана; Петровиц, Владимир П.; Петровиц, Зорица Д.; Доровиц, Јелена; Симијоновиц, Дусица; | |
dc.citation.volume | 72 | |
dc.citation.issue | 9 | |
dc.citation.spage | 2171 | |
dc.citation.epage | 2180 | |
dc.identifier.wos | 000440149500006 | |
dc.identifier.doi | 10.1007/s11696-018-0419-5 | |
dc.citation.other | 72(9): 2171-2180 | |
dc.citation.rank | M23 | |
dc.description.other | Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3209] | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-85050726703 |