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Voltammetric Study of Antitumor Efficient Ethylenediamine-Type of Ligands

Authorized Users Only
2018
Authors
Mihajlović-Lalić, Ljiljana
Stanković, Dalibor
Poljarević, Jelena
Sabo, Tibor
Manojlović, Dragan D.
Article (Published version)
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Abstract
The electrochemical behavior of four dialkyl esters (methyl, ethyl, n-propyl and n-butyl) of (S,S)-alpha,alpha'-(1,2-ethanediyldiimino)-bis[cyclohexanepropanoic acid] with moderate antitumor activity has been studied by cyclic voltammetry. I-E curves recorded at boron-doped diamond electrode in -2.00 lt E-p lt 0.00 V range show a single oxidative peak located in the -0.95 lt E-p,E-a lt -0.52 V region in a form of one-electron wave. The electrochemical processes appear to be irreversible for all compounds except for the compound with methyl substituent which demonstrates well-defined reversible electron transfer. Derivatives with bulkier moieties are easier to oxidize. For all investigated compounds an amine-centered redox process is dominant. Further investigation indicates that electrochemical reaction is diffusion controlled, chemically irreversible process. The results are discussed in terms of linking their electrochemical activity to antitumor effect. (C) 2018 The Electroc...hemical Society.

Source:
Journal of the Electrochemical Society, 2018, 165, 10
Publisher:
  • Electrochemical Soc Inc, Pennington
Funding / projects:
  • Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-172035)
  • Application of advanced oxidation processes and nanostructured oxide materials for the removal of pollutants from the environment, development and optimisation of instrumental techniques for efficiency monitoring (RS-172030)
  • Strengthening of the MagBioVin Research and Innovation Team for Development of Novel Approaches for Tumour Therapy based on Nanostructured Materials (EU-621375)

DOI: 10.1149/2.1121810jes

ISSN: 0013-4651

WoS: 000441061800121

Scopus: 2-s2.0-85053785892
[ Google Scholar ]
1
1
URI
https://cherry.chem.bg.ac.rs/handle/123456789/2196
Collections
  • Publikacije
  • Publikacije
Institution/Community
Hemijski fakultet
TY  - JOUR
AU  - Mihajlović-Lalić, Ljiljana
AU  - Stanković, Dalibor
AU  - Poljarević, Jelena
AU  - Sabo, Tibor
AU  - Manojlović, Dragan D.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2196
AB  - The electrochemical behavior of four dialkyl esters (methyl, ethyl, n-propyl and n-butyl) of (S,S)-alpha,alpha'-(1,2-ethanediyldiimino)-bis[cyclohexanepropanoic acid] with moderate antitumor activity has been studied by cyclic voltammetry. I-E curves recorded at boron-doped diamond electrode in -2.00  lt  E-p  lt  0.00 V range show a single oxidative peak located in the -0.95  lt  E-p,E-a  lt  -0.52 V region in a form of one-electron wave. The electrochemical processes appear to be irreversible for all compounds except for the compound with methyl substituent which demonstrates well-defined reversible electron transfer. Derivatives with bulkier moieties are easier to oxidize. For all investigated compounds an amine-centered redox process is dominant. Further investigation indicates that electrochemical reaction is diffusion controlled, chemically irreversible process. The results are discussed in terms of linking their electrochemical activity to antitumor effect. (C) 2018 The Electrochemical Society.
PB  - Electrochemical Soc Inc, Pennington
T2  - Journal of the Electrochemical Society
T1  - Voltammetric Study of Antitumor Efficient Ethylenediamine-Type of Ligands
VL  - 165
IS  - 10
DO  - 10.1149/2.1121810jes
UR  - Kon_3527
ER  - 
@article{
author = "Mihajlović-Lalić, Ljiljana and Stanković, Dalibor and Poljarević, Jelena and Sabo, Tibor and Manojlović, Dragan D.",
year = "2018",
abstract = "The electrochemical behavior of four dialkyl esters (methyl, ethyl, n-propyl and n-butyl) of (S,S)-alpha,alpha'-(1,2-ethanediyldiimino)-bis[cyclohexanepropanoic acid] with moderate antitumor activity has been studied by cyclic voltammetry. I-E curves recorded at boron-doped diamond electrode in -2.00  lt  E-p  lt  0.00 V range show a single oxidative peak located in the -0.95  lt  E-p,E-a  lt  -0.52 V region in a form of one-electron wave. The electrochemical processes appear to be irreversible for all compounds except for the compound with methyl substituent which demonstrates well-defined reversible electron transfer. Derivatives with bulkier moieties are easier to oxidize. For all investigated compounds an amine-centered redox process is dominant. Further investigation indicates that electrochemical reaction is diffusion controlled, chemically irreversible process. The results are discussed in terms of linking their electrochemical activity to antitumor effect. (C) 2018 The Electrochemical Society.",
publisher = "Electrochemical Soc Inc, Pennington",
journal = "Journal of the Electrochemical Society",
title = "Voltammetric Study of Antitumor Efficient Ethylenediamine-Type of Ligands",
volume = "165",
number = "10",
doi = "10.1149/2.1121810jes",
url = "Kon_3527"
}
Mihajlović-Lalić, L., Stanković, D., Poljarević, J., Sabo, T.,& Manojlović, D. D.. (2018). Voltammetric Study of Antitumor Efficient Ethylenediamine-Type of Ligands. in Journal of the Electrochemical Society
Electrochemical Soc Inc, Pennington., 165(10).
https://doi.org/10.1149/2.1121810jes
Kon_3527
Mihajlović-Lalić L, Stanković D, Poljarević J, Sabo T, Manojlović DD. Voltammetric Study of Antitumor Efficient Ethylenediamine-Type of Ligands. in Journal of the Electrochemical Society. 2018;165(10).
doi:10.1149/2.1121810jes
Kon_3527 .
Mihajlović-Lalić, Ljiljana, Stanković, Dalibor, Poljarević, Jelena, Sabo, Tibor, Manojlović, Dragan D., "Voltammetric Study of Antitumor Efficient Ethylenediamine-Type of Ligands" in Journal of the Electrochemical Society, 165, no. 10 (2018),
https://doi.org/10.1149/2.1121810jes .,
Kon_3527 .

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