Benzothiazole carbamates and amides as antiproliferative species
Samo za registrovane korisnike
2018
Autori
Videnović, MilicaMojsin, Marija
Stevanović, Milena
Opsenica, Igor
Srdić-Rajić, Tatjana
Šolaja, Bogdan A.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, sub-micromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness. (C) 2018 Elsevier Masson SAS. All rights reserved.
Ključne reči:
Benzothiazoles / Antiproliferative / MCF-7 / NT2/D1 / AnoikisIzvor:
European Journal of Medicinal Chemistry, 2018, 157, 1096-1114Izdavač:
- Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
Finansiranje / projekti:
- Sinteza aminohinolina i njihovih derivata kao antimalarika i inhibitora botulinum neurotoksina A (RS-MESTD-Basic Research (BR or ON)-172008)
- Proučavanje signalnih puteva i epigenetičkih mehanizama uključenih u kontrolu ekspresije humanih SOX gena: dalje rasvetljavanje njihove uloge u određivanju sudbine i diferencijaciji ćelija (RS-MESTD-Basic Research (BR or ON)-173051)
- Serbian Academy of Sciences and Arts
Napomena:
- Peer-reviewed manuscript: http://cherry.chem.bg.ac.rs/handle/123456789/2960
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/2961
DOI: 10.1016/j.ejmech.2018.08.067
ISSN: 0223-5234
PubMed: 30179747
WoS: 000447480000079
Scopus: 2-s2.0-85054063702
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Videnović, Milica AU - Mojsin, Marija AU - Stevanović, Milena AU - Opsenica, Igor AU - Srdić-Rajić, Tatjana AU - Šolaja, Bogdan A. PY - 2018 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2233 AB - A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, sub-micromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness. (C) 2018 Elsevier Masson SAS. All rights reserved. PB - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux T2 - European Journal of Medicinal Chemistry T1 - Benzothiazole carbamates and amides as antiproliferative species VL - 157 SP - 1096 EP - 1114 DO - 10.1016/j.ejmech.2018.08.067 ER -
@article{ author = "Videnović, Milica and Mojsin, Marija and Stevanović, Milena and Opsenica, Igor and Srdić-Rajić, Tatjana and Šolaja, Bogdan A.", year = "2018", abstract = "A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, sub-micromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness. (C) 2018 Elsevier Masson SAS. All rights reserved.", publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux", journal = "European Journal of Medicinal Chemistry", title = "Benzothiazole carbamates and amides as antiproliferative species", volume = "157", pages = "1096-1114", doi = "10.1016/j.ejmech.2018.08.067" }
Videnović, M., Mojsin, M., Stevanović, M., Opsenica, I., Srdić-Rajić, T.,& Šolaja, B. A.. (2018). Benzothiazole carbamates and amides as antiproliferative species. in European Journal of Medicinal Chemistry Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 157, 1096-1114. https://doi.org/10.1016/j.ejmech.2018.08.067
Videnović M, Mojsin M, Stevanović M, Opsenica I, Srdić-Rajić T, Šolaja BA. Benzothiazole carbamates and amides as antiproliferative species. in European Journal of Medicinal Chemistry. 2018;157:1096-1114. doi:10.1016/j.ejmech.2018.08.067 .
Videnović, Milica, Mojsin, Marija, Stevanović, Milena, Opsenica, Igor, Srdić-Rajić, Tatjana, Šolaja, Bogdan A., "Benzothiazole carbamates and amides as antiproliferative species" in European Journal of Medicinal Chemistry, 157 (2018):1096-1114, https://doi.org/10.1016/j.ejmech.2018.08.067 . .