Faculty of Chemistry Repository - Cherry
University of Belgrade - Faculty of Chemistry
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   Cherry
  • Hemijski fakultet
  • Publikacije
  • View Item
  •   Cherry
  • Hemijski fakultet
  • Publikacije
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up

Authorized Users Only
2016
Authors
Atanasković-Marković, Marina
Gaeta, Francesco
Međo, Biljana
Gavrović-Jankulović, Marija
Ćirković-Veličković, Tanja
Tmušić, Vladimir
Romano, Antonino
Article (Published version)
Metadata
Show full item record
Abstract
BackgroundNon-immediate reactions to beta-lactam antibiotics (BL) occur more than one hour after drug administration, and the most common manifestations are maculopapular exanthemas and delayed-appearing urticaria and/or angioedema. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions (DHR), if a drug is taken at the same time. The most of children are labeled as drug allergic' after considering only the clinical history. ObjectiveTo diagnose/detect a hypersensitivity or an infection which mimic DHR in children with non-immediate reactions to BL MethodsA prospective survey was conducted in a group of 1026 children with histories of non-immediate reactions to BL by performing patch tests, skin tests, and in case of negative results, drug provocation tests (DPTs). In 300 children, a study was performed to detect infections by viruses or Mycoplasma pneumoniae. ResultsUrticaria and maculopapular exanthemas were the most reported non-immediate reactions. Only 76 (...7.4%) of 1026 children had confirmed non-immediate hypersensitivity reactions to BL. Fifty-seven children had positive delayed-reading intradermal tests (18 of these with a positive patch test). Nineteen children had positive DPT. Sixty-six of 300 children had positive tests for viruses or Mycoplasma pneumoniae and 2 of them had a positive allergy work-up. ConclusionsA diagnostic work-up should be performed in all children with non-immediate reactions to BL, to remove a false label of hypersensitivity. Even though only 57 (5.5%) of 1026 children displayed positive responses to delayed-reading intradermal tests to BL, such tests appear to be useful in order to reduce the risk for positive DPTs.

Keywords:
allergy work-up / beta-lactams / children / non-immediate hypersensitivity reactions / provocation test / skin test
Source:
Pediatric Allergy and Immunology, 2016, 27, 5, 533-538
Publisher:
  • Wiley, Hoboken
Funding / projects:
  • Molecular properties and modifications of some respiratory and nutritional allergens (RS-172024)
  • Allergens, antibodies, enzymes and small physiologically important molecules: design, structure, function and relevance (RS-172049)

DOI: 10.1111/pai.12565

ISSN: 0905-6157

PubMed: 26999792

WoS: 000379928100014

Scopus: 2-s2.0-84978264083
[ Google Scholar ]
65
61
URI
https://cherry.chem.bg.ac.rs/handle/123456789/2278
Collections
  • Publikacije
Institution/Community
Hemijski fakultet
TY  - JOUR
AU  - Atanasković-Marković, Marina
AU  - Gaeta, Francesco
AU  - Međo, Biljana
AU  - Gavrović-Jankulović, Marija
AU  - Ćirković-Veličković, Tanja
AU  - Tmušić, Vladimir
AU  - Romano, Antonino
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2278
AB  - BackgroundNon-immediate reactions to beta-lactam antibiotics (BL) occur more than one hour after drug administration, and the most common manifestations are maculopapular exanthemas and delayed-appearing urticaria and/or angioedema. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions (DHR), if a drug is taken at the same time. The most of children are labeled as drug allergic' after considering only the clinical history. ObjectiveTo diagnose/detect a hypersensitivity or an infection which mimic DHR in children with non-immediate reactions to BL MethodsA prospective survey was conducted in a group of 1026 children with histories of non-immediate reactions to BL by performing patch tests, skin tests, and in case of negative results, drug provocation tests (DPTs). In 300 children, a study was performed to detect infections by viruses or Mycoplasma pneumoniae. ResultsUrticaria and maculopapular exanthemas were the most reported non-immediate reactions. Only 76 (7.4%) of 1026 children had confirmed non-immediate hypersensitivity reactions to BL. Fifty-seven children had positive delayed-reading intradermal tests (18 of these with a positive patch test). Nineteen children had positive DPT. Sixty-six of 300 children had positive tests for viruses or Mycoplasma pneumoniae and 2 of them had a positive allergy work-up. ConclusionsA diagnostic work-up should be performed in all children with non-immediate reactions to BL, to remove a false label of hypersensitivity. Even though only 57 (5.5%) of 1026 children displayed positive responses to delayed-reading intradermal tests to BL, such tests appear to be useful in order to reduce the risk for positive DPTs.
PB  - Wiley, Hoboken
T2  - Pediatric Allergy and Immunology
T1  - Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up
VL  - 27
IS  - 5
SP  - 533
EP  - 538
DO  - 10.1111/pai.12565
UR  - Kon_3094
ER  - 
@article{
author = "Atanasković-Marković, Marina and Gaeta, Francesco and Međo, Biljana and Gavrović-Jankulović, Marija and Ćirković-Veličković, Tanja and Tmušić, Vladimir and Romano, Antonino",
year = "2016",
abstract = "BackgroundNon-immediate reactions to beta-lactam antibiotics (BL) occur more than one hour after drug administration, and the most common manifestations are maculopapular exanthemas and delayed-appearing urticaria and/or angioedema. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions (DHR), if a drug is taken at the same time. The most of children are labeled as drug allergic' after considering only the clinical history. ObjectiveTo diagnose/detect a hypersensitivity or an infection which mimic DHR in children with non-immediate reactions to BL MethodsA prospective survey was conducted in a group of 1026 children with histories of non-immediate reactions to BL by performing patch tests, skin tests, and in case of negative results, drug provocation tests (DPTs). In 300 children, a study was performed to detect infections by viruses or Mycoplasma pneumoniae. ResultsUrticaria and maculopapular exanthemas were the most reported non-immediate reactions. Only 76 (7.4%) of 1026 children had confirmed non-immediate hypersensitivity reactions to BL. Fifty-seven children had positive delayed-reading intradermal tests (18 of these with a positive patch test). Nineteen children had positive DPT. Sixty-six of 300 children had positive tests for viruses or Mycoplasma pneumoniae and 2 of them had a positive allergy work-up. ConclusionsA diagnostic work-up should be performed in all children with non-immediate reactions to BL, to remove a false label of hypersensitivity. Even though only 57 (5.5%) of 1026 children displayed positive responses to delayed-reading intradermal tests to BL, such tests appear to be useful in order to reduce the risk for positive DPTs.",
publisher = "Wiley, Hoboken",
journal = "Pediatric Allergy and Immunology",
title = "Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up",
volume = "27",
number = "5",
pages = "533-538",
doi = "10.1111/pai.12565",
url = "Kon_3094"
}
Atanasković-Marković, M., Gaeta, F., Međo, B., Gavrović-Jankulović, M., Ćirković-Veličković, T., Tmušić, V.,& Romano, A.. (2016). Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up. in Pediatric Allergy and Immunology
Wiley, Hoboken., 27(5), 533-538.
https://doi.org/10.1111/pai.12565
Kon_3094
Atanasković-Marković M, Gaeta F, Međo B, Gavrović-Jankulović M, Ćirković-Veličković T, Tmušić V, Romano A. Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up. in Pediatric Allergy and Immunology. 2016;27(5):533-538.
doi:10.1111/pai.12565
Kon_3094 .
Atanasković-Marković, Marina, Gaeta, Francesco, Međo, Biljana, Gavrović-Jankulović, Marija, Ćirković-Veličković, Tanja, Tmušić, Vladimir, Romano, Antonino, "Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up" in Pediatric Allergy and Immunology, 27, no. 5 (2016):533-538,
https://doi.org/10.1111/pai.12565 .,
Kon_3094 .

DSpace software copyright © 2002-2015  DuraSpace
About CHERRY - CHEmistry RepositoRY | Send Feedback

re3dataOpenAIRERCUB
 

 

All of DSpaceInstitutions/communitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About CHERRY - CHEmistry RepositoRY | Send Feedback

re3dataOpenAIRERCUB