Cytotoxic Pt(IV) and Ru(II) complexes containing a biologically relevant edda-type ligand: A comparative study of their thermal properties
2016
Authors
Mihajlović-Lalić, LjiljanaDamjanovic, Ljiljana
Šumar-Ristović, Maja
Savić, Aleksandar
Sabo, Tibor
Dondur, Vera
Grgurić-Šipka, Sanja
Article (Published version)
Metadata
Show full item recordAbstract
The thermal behaviour of a Pt(IV) and a Ru(II) complex coordinated to dibutyl (S,S)-alpha,alpha'-(1,2-ethanediyldiimino)biscyclohexanepropanoate was investigated using thermogravimetry (TG) and differential scanning calorimetry (DSC). The study included an investigation of the thermal decomposition of these complexes in the temperature range of 30 to 590 degrees C and an evaluation of the activation energy for the first decomposition steps. For both metal complexes, broad DSC peaks indicated complex thermal transformation processes. The two-step decomposition of the Pt(IV) complex started at 175 and ended at about 418 degrees C, leaving elemental platinum as the final residue. On the other hand, the Ru(II) analogue decomposed in three stages. Thermal degradation was evident beginning at 144 degrees C and suggested the decomposition of a coordinated ligand as the dominant process. For this complex, the proposed final residue was RuO2. Kinetic parameters for the first decomposition step ...were obtained by means of the multi-heating rates method, in this case the Kissinger-Akahira-Sunose (KAS) method. The mean activation energy calculated for 0.2 lt alpha lt 0.8 were 122.0 kJ mol(-1) for the Pt(IV) and 118.9 kJ mol(-1) for the Ru(II) complex and decreased constantly, a characteristic of a multi-step process.
Keywords:
platinum (IV) complex / ruthenium (II) complex / anti-tumor activity / activation energy / TG-DSCSource:
Journal of the Serbian Chemical Society, 2016, 81, 8, 897-905Publisher:
- Serbian Chemical Soc, Belgrade
Funding / projects:
- Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-MESTD-Basic Research (BR or ON)-172035)
- Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-MESTD-Basic Research (BR or ON)-172055)
- Oxide-based environmentally-friendly porous materials for genotoxic substances removal (RS-MESTD-Basic Research (BR or ON)-172018)
Note:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3434
DOI: 10.2298/JSC160320059M
ISSN: 0352-5139
WoS: 000384930600005
Scopus: 2-s2.0-84987810051
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Mihajlović-Lalić, Ljiljana AU - Damjanovic, Ljiljana AU - Šumar-Ristović, Maja AU - Savić, Aleksandar AU - Sabo, Tibor AU - Dondur, Vera AU - Grgurić-Šipka, Sanja PY - 2016 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2325 AB - The thermal behaviour of a Pt(IV) and a Ru(II) complex coordinated to dibutyl (S,S)-alpha,alpha'-(1,2-ethanediyldiimino)biscyclohexanepropanoate was investigated using thermogravimetry (TG) and differential scanning calorimetry (DSC). The study included an investigation of the thermal decomposition of these complexes in the temperature range of 30 to 590 degrees C and an evaluation of the activation energy for the first decomposition steps. For both metal complexes, broad DSC peaks indicated complex thermal transformation processes. The two-step decomposition of the Pt(IV) complex started at 175 and ended at about 418 degrees C, leaving elemental platinum as the final residue. On the other hand, the Ru(II) analogue decomposed in three stages. Thermal degradation was evident beginning at 144 degrees C and suggested the decomposition of a coordinated ligand as the dominant process. For this complex, the proposed final residue was RuO2. Kinetic parameters for the first decomposition step were obtained by means of the multi-heating rates method, in this case the Kissinger-Akahira-Sunose (KAS) method. The mean activation energy calculated for 0.2 lt alpha lt 0.8 were 122.0 kJ mol(-1) for the Pt(IV) and 118.9 kJ mol(-1) for the Ru(II) complex and decreased constantly, a characteristic of a multi-step process. PB - Serbian Chemical Soc, Belgrade T2 - Journal of the Serbian Chemical Society T1 - Cytotoxic Pt(IV) and Ru(II) complexes containing a biologically relevant edda-type ligand: A comparative study of their thermal properties VL - 81 IS - 8 SP - 897 EP - 905 DO - 10.2298/JSC160320059M ER -
@article{ author = "Mihajlović-Lalić, Ljiljana and Damjanovic, Ljiljana and Šumar-Ristović, Maja and Savić, Aleksandar and Sabo, Tibor and Dondur, Vera and Grgurić-Šipka, Sanja", year = "2016", abstract = "The thermal behaviour of a Pt(IV) and a Ru(II) complex coordinated to dibutyl (S,S)-alpha,alpha'-(1,2-ethanediyldiimino)biscyclohexanepropanoate was investigated using thermogravimetry (TG) and differential scanning calorimetry (DSC). The study included an investigation of the thermal decomposition of these complexes in the temperature range of 30 to 590 degrees C and an evaluation of the activation energy for the first decomposition steps. For both metal complexes, broad DSC peaks indicated complex thermal transformation processes. The two-step decomposition of the Pt(IV) complex started at 175 and ended at about 418 degrees C, leaving elemental platinum as the final residue. On the other hand, the Ru(II) analogue decomposed in three stages. Thermal degradation was evident beginning at 144 degrees C and suggested the decomposition of a coordinated ligand as the dominant process. For this complex, the proposed final residue was RuO2. Kinetic parameters for the first decomposition step were obtained by means of the multi-heating rates method, in this case the Kissinger-Akahira-Sunose (KAS) method. The mean activation energy calculated for 0.2 lt alpha lt 0.8 were 122.0 kJ mol(-1) for the Pt(IV) and 118.9 kJ mol(-1) for the Ru(II) complex and decreased constantly, a characteristic of a multi-step process.", publisher = "Serbian Chemical Soc, Belgrade", journal = "Journal of the Serbian Chemical Society", title = "Cytotoxic Pt(IV) and Ru(II) complexes containing a biologically relevant edda-type ligand: A comparative study of their thermal properties", volume = "81", number = "8", pages = "897-905", doi = "10.2298/JSC160320059M" }
Mihajlović-Lalić, L., Damjanovic, L., Šumar-Ristović, M., Savić, A., Sabo, T., Dondur, V.,& Grgurić-Šipka, S.. (2016). Cytotoxic Pt(IV) and Ru(II) complexes containing a biologically relevant edda-type ligand: A comparative study of their thermal properties. in Journal of the Serbian Chemical Society Serbian Chemical Soc, Belgrade., 81(8), 897-905. https://doi.org/10.2298/JSC160320059M
Mihajlović-Lalić L, Damjanovic L, Šumar-Ristović M, Savić A, Sabo T, Dondur V, Grgurić-Šipka S. Cytotoxic Pt(IV) and Ru(II) complexes containing a biologically relevant edda-type ligand: A comparative study of their thermal properties. in Journal of the Serbian Chemical Society. 2016;81(8):897-905. doi:10.2298/JSC160320059M .
Mihajlović-Lalić, Ljiljana, Damjanovic, Ljiljana, Šumar-Ristović, Maja, Savić, Aleksandar, Sabo, Tibor, Dondur, Vera, Grgurić-Šipka, Sanja, "Cytotoxic Pt(IV) and Ru(II) complexes containing a biologically relevant edda-type ligand: A comparative study of their thermal properties" in Journal of the Serbian Chemical Society, 81, no. 8 (2016):897-905, https://doi.org/10.2298/JSC160320059M . .