Microwave-assisted synthesis of azepines via nucleophilic aromatic substitution
Apstrakt
A novel and efficient route has been developed to afford dipyridoazepine derivatives from primary amines and 3,3'-(Z)-ethene-1,2-diylbis(4-chloropyridine). The procedure based on a double nucleophilic aromatic substitution provides a valuable synthetic tool for the synthesis of dipyridoazepines. The reaction proceeds without catalyst, under microwave irradiation conditions.
Ključne reči:
azepines / heterocycles / nucleophilic aromatic substitution / transition metal-free conditions / microwave irradiationIzvor:
Journal of the Serbian Chemical Society, 2016, 81, 11, 1225-1230Izdavač:
- Serbian Chemical Soc, Belgrade
Finansiranje / projekti:
- Sinteza aminohinolina i njihovih derivata kao antimalarika i inhibitora botulinum neurotoksina A (RS-MESTD-Basic Research (BR or ON)-172008)
- Serbian Academy of Sciences and Arts
Napomena:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3567
DOI: 10.2298/JSC160824074B
ISSN: 0352-5139
WoS: 000388618600001
Scopus: 2-s2.0-84998678147
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Božinović, Nina S. AU - Šolaja, Bogdan A. AU - Opsenica, Igor PY - 2016 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2354 AB - A novel and efficient route has been developed to afford dipyridoazepine derivatives from primary amines and 3,3'-(Z)-ethene-1,2-diylbis(4-chloropyridine). The procedure based on a double nucleophilic aromatic substitution provides a valuable synthetic tool for the synthesis of dipyridoazepines. The reaction proceeds without catalyst, under microwave irradiation conditions. PB - Serbian Chemical Soc, Belgrade T2 - Journal of the Serbian Chemical Society T1 - Microwave-assisted synthesis of azepines via nucleophilic aromatic substitution VL - 81 IS - 11 SP - 1225 EP - 1230 DO - 10.2298/JSC160824074B ER -
@article{ author = "Božinović, Nina S. and Šolaja, Bogdan A. and Opsenica, Igor", year = "2016", abstract = "A novel and efficient route has been developed to afford dipyridoazepine derivatives from primary amines and 3,3'-(Z)-ethene-1,2-diylbis(4-chloropyridine). The procedure based on a double nucleophilic aromatic substitution provides a valuable synthetic tool for the synthesis of dipyridoazepines. The reaction proceeds without catalyst, under microwave irradiation conditions.", publisher = "Serbian Chemical Soc, Belgrade", journal = "Journal of the Serbian Chemical Society", title = "Microwave-assisted synthesis of azepines via nucleophilic aromatic substitution", volume = "81", number = "11", pages = "1225-1230", doi = "10.2298/JSC160824074B" }
Božinović, N. S., Šolaja, B. A.,& Opsenica, I.. (2016). Microwave-assisted synthesis of azepines via nucleophilic aromatic substitution. in Journal of the Serbian Chemical Society Serbian Chemical Soc, Belgrade., 81(11), 1225-1230. https://doi.org/10.2298/JSC160824074B
Božinović NS, Šolaja BA, Opsenica I. Microwave-assisted synthesis of azepines via nucleophilic aromatic substitution. in Journal of the Serbian Chemical Society. 2016;81(11):1225-1230. doi:10.2298/JSC160824074B .
Božinović, Nina S., Šolaja, Bogdan A., Opsenica, Igor, "Microwave-assisted synthesis of azepines via nucleophilic aromatic substitution" in Journal of the Serbian Chemical Society, 81, no. 11 (2016):1225-1230, https://doi.org/10.2298/JSC160824074B . .