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dc.creatorStanković, Slaviša
dc.creatorDimkić, Ivica
dc.creatorVujisić, Ljubodrag V.
dc.creatorPavković-Lučić, Sofija
dc.creatorJovanović, Zvezdana
dc.creatorStević, Tatjana
dc.creatorSofrenić, Ivana V.
dc.creatorMitić, Bojan M.
dc.creatorTomić, Vladimir T.
dc.date.accessioned2018-11-22T00:37:35Z
dc.date.available2018-11-22T00:37:35Z
dc.date.issued2016
dc.identifier.issn1932-6203
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/2363
dc.description.abstractThe chemical defence of the millipede Pachyiulus hungaricus is reported in the present paper, in which a chemical characterization is given and antimicrobial activity is determined. In total, independently of sex, 44 compounds were identified. All compounds belong to two groups: quinones and pentyl and hexyl esters of long-chain fatty acids. The relative abundances of quinones and non-quinones were 94.7% vs. 5.3% (males) and 87.3% vs. 12.7% (females), respectively. The two dominant quinones in both sexes were 2-methyl-1,4,-benzoquinone and 2-methoxy-3-methyl-1,4-benzoquinone. Antibacterial and antifungal activity of the defensive secretion was evaluated in vitro against seven bacterial strains and eight fungal species. With the aid of a dilution technique, the antimicrobial potential of the secretion and high sensitivity of all tested strains were confirmed. The lowest minimum concentrations of these compounds (0.20-0.25 mg/mL) were sufficient for inhibition of Aeromonas hydrophila, Listeria monocytogenes and Methicillin resistant Staphylococcus aureus (MRSA). The growth of eight tested fungal species was inhibited by slightly lower concentrations of the secretion, with Fusarium equisetias the most sensitive fungus and Aspergillus flavus as the most resistant. Values of MIC and MFC in the employed microdilution assay ranged from 0.10 to above 0.35 mg/m L. The given extract contains antimicrobial components potentially useful as therapeutic agents in the pharmaceutical and agricultural industries.en
dc.publisherPublic Library Science, San Francisco
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173026/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173038/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.rightsopenAccess
dc.sourcePLoS One / Public Library of Science
dc.titleChemical Defence in a Millipede: Evaluation and Characterization of Antimicrobial Activity of the Defensive Secretion from Pachyiulus hungaricus (Karsch, 1881) (Diplopoda, Julida, Julidae)en
dc.typearticle
dc.rights.licenseBY
dcterms.abstractСофрениц, Ивана; Станковиц, Слависа; Димкиц, Ивица; Вујисић, Љубодраг; Павковиц-Луциц, Софија; Томиц, Владимир; Стевиц, Татјана; Јовановиц, Звездана; Митиц, Бојан;
dc.citation.volume11
dc.citation.issue12
dc.identifier.wos000389482700103
dc.identifier.doi10.1371/journal.pone.0167249
dc.citation.other11(12): e0167249
dc.citation.rankM21
dc.identifier.pmid27907048
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-84999723803
dc.identifier.fulltexthttp://cherry.chem.bg.ac.rs/bitstream/id/9343/2361.pdf
dc.identifier.rcubKon_3179


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