Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment
Authorized Users Only
2016
Authors
Spasojević, DragicaZmejkoski, Danica

Glamočlija, Jasmina

Nikolić, Miloš
Soković, Marina

Milošević, Verica
Jarić, Ivana
Stojanović, Marijana M.

Marinković, Emilija
Barisani-Asenbauer, Talin

Prodanović, Radivoje

Jovanović, Miloš
Radotić, Ksenija

Article (Published version)

Metadata
Show full item recordAbstract
Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP-Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments. (C) 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
Keywords:
Lignin model polymer / Alginate / Antimicrobial activity / Bacterial biofilm / Wound treatmentSource:
International Journal of Antimicrobial Agents, 2016, 48, 6, 732-735Publisher:
- Elsevier Science Bv, Amsterdam
Funding / projects:
- Synthesis, processing and characterization of nanostructured materials for application in the field of energy, mechanical engineering, environmental protection and biomedicine (RS-45012)
- Study of structure-function relationships in the plant cell wall and modifications of the wall structure by enzyme engineering (RS-173017)
- Characterization and application of fungal metabolites and assessment of new biofungicides potential (RS-173032)
- Allergens, antibodies, enzymes and small physiologically important molecules: design, structure, function and relevance (RS-172049)
Note:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3560
DOI: 10.1016/j.ijantimicag.2016.08.014
ISSN: 0924-8579
PubMed: 27742207
WoS: 000389520700024
Scopus: 2-s2.0-85000995852
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Spasojević, Dragica AU - Zmejkoski, Danica AU - Glamočlija, Jasmina AU - Nikolić, Miloš AU - Soković, Marina AU - Milošević, Verica AU - Jarić, Ivana AU - Stojanović, Marijana M. AU - Marinković, Emilija AU - Barisani-Asenbauer, Talin AU - Prodanović, Radivoje AU - Jovanović, Miloš AU - Radotić, Ksenija PY - 2016 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2364 AB - Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP-Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments. (C) 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved. PB - Elsevier Science Bv, Amsterdam T2 - International Journal of Antimicrobial Agents T1 - Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment VL - 48 IS - 6 SP - 732 EP - 735 DO - 10.1016/j.ijantimicag.2016.08.014 ER -
@article{ author = "Spasojević, Dragica and Zmejkoski, Danica and Glamočlija, Jasmina and Nikolić, Miloš and Soković, Marina and Milošević, Verica and Jarić, Ivana and Stojanović, Marijana M. and Marinković, Emilija and Barisani-Asenbauer, Talin and Prodanović, Radivoje and Jovanović, Miloš and Radotić, Ksenija", year = "2016", abstract = "Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP-Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments. (C) 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.", publisher = "Elsevier Science Bv, Amsterdam", journal = "International Journal of Antimicrobial Agents", title = "Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment", volume = "48", number = "6", pages = "732-735", doi = "10.1016/j.ijantimicag.2016.08.014" }
Spasojević, D., Zmejkoski, D., Glamočlija, J., Nikolić, M., Soković, M., Milošević, V., Jarić, I., Stojanović, M. M., Marinković, E., Barisani-Asenbauer, T., Prodanović, R., Jovanović, M.,& Radotić, K.. (2016). Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment. in International Journal of Antimicrobial Agents Elsevier Science Bv, Amsterdam., 48(6), 732-735. https://doi.org/10.1016/j.ijantimicag.2016.08.014
Spasojević D, Zmejkoski D, Glamočlija J, Nikolić M, Soković M, Milošević V, Jarić I, Stojanović MM, Marinković E, Barisani-Asenbauer T, Prodanović R, Jovanović M, Radotić K. Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment. in International Journal of Antimicrobial Agents. 2016;48(6):732-735. doi:10.1016/j.ijantimicag.2016.08.014 .
Spasojević, Dragica, Zmejkoski, Danica, Glamočlija, Jasmina, Nikolić, Miloš, Soković, Marina, Milošević, Verica, Jarić, Ivana, Stojanović, Marijana M., Marinković, Emilija, Barisani-Asenbauer, Talin, Prodanović, Radivoje, Jovanović, Miloš, Radotić, Ksenija, "Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment" in International Journal of Antimicrobial Agents, 48, no. 6 (2016):732-735, https://doi.org/10.1016/j.ijantimicag.2016.08.014 . .