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Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation
dc.creator | Baroud, Afya A. | |
dc.creator | Mihajlović-Lalić, Ljiljana | |
dc.creator | Gligorijević, Nevenka | |
dc.creator | Aranđelović, Sandra | |
dc.creator | Stanković, Dalibor | |
dc.creator | Radulović, Siniša | |
dc.creator | Van Hecke, Kristof | |
dc.creator | Savić, Aleksandar | |
dc.creator | Grgurić-Šipka, Sanja | |
dc.date.accessioned | 2018-11-22T00:39:32Z | |
dc.date.available | 2018-01-17T00:39:32Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0095-8972 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/2423 | |
dc.description.abstract | Complexes 1-4, [Ru(L)(bpy)(2)]PF6, where bpy=2,2-bipyridine; HL=3-methylpyridine-2-carboxylic acid (HL1), 6-methylpyridine-2-carboxylic acid (HL2), 5-bromopyridine-2-carboxylic acid (HL3) and 6-bromopyridine-2-carboxylic acid (HL4), were synthesized and characterized. The electrochemical character of the complexes was investigated by cyclic voltammetry revealing two reversible reduction waves in the negative range of potentials, most likely due to a reduction of the bipyridine moiety. Cytotoxicity studies by MTT assay for 72h of drug action revealed that 2-4 exhibited moderate activity in cervical human tumor cells (HeLa). Complex 2 exhibited low activity in colon cancer LS-174 cells (180 +/- 10), while all complexes were devoid of activity in lung cancer A549 and non-tumor MRC-5 cells, up to 200M. Combinational studies of the most active complex 2, with pharmacological modulators of cell redox status, L-buthionine-sulfoximine (L-BSO) or N-acetyl-L-cysteine (NAC), showed that when L-BSO potentiated, 2 induced a sub-G1 peak of the cell cycle in the HeLa cell line. UV-vis and cyclic voltammetry were performed in order to investigate the binding mode of 2 to DNA and suggested intercalation for the complex-DNA interaction. [GRAPHICS] | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS// | |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/256716/EU// | |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/621375/EU// | |
dc.relation | Research Fund-Flanders (FWO) | |
dc.relation | Hercules Foundation (3D-SPACE: 3D Structural Platform Aiming for Chemical Excellence) [AUGE/11/029] | |
dc.rights | embargoedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of Coordination Chemistry | |
dc.subject | Ruthenium(II) bipyridine complexes | en |
dc.subject | crystal structure | en |
dc.subject | redox properties | en |
dc.subject | cytotoxicity | en |
dc.subject | DNA intercalation | en |
dc.title | Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Михајловић-Лалић, Љиљана; Станковић, Далибор; Савић, Aлександар; Гргурић-Шипка, Сања; Радуловиц, Синиса; Бароуд, Aфyа A.; Глигоријевиц, Невенка; Aранделовиц, Сандра; Ван Хецке, Кристоф; | |
dc.citation.volume | 70 | |
dc.citation.issue | 5 | |
dc.citation.spage | 831 | |
dc.citation.epage | 847 | |
dc.identifier.wos | 000395175800006 | |
dc.identifier.doi | 10.1080/00958972.2017.1282611 | |
dc.citation.other | 70(5): 831-847 | |
dc.citation.rank | M22 | |
dc.description.other | This is the peer-reviewed version of the following article: Baroud, A. A.; Mihajlović-Lalić, L. E.; Gligorijević, N.; Aranđelović, S.; Stanković, D.; Radulović, S.; Van Hecke, K.; Savić, A.; Grgurić-Šipka, S. Ruthenium(II) Bipyridine Complexes: From Synthesis and Crystal Structures to Electrochemical and Cytotoxicity Investigation. Journal of Coordination Chemistry 2017, 70 (5), 831–847. [https://doi.org/10.1080/00958972.2017.1282611] | |
dc.description.other | Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3138] | |
dc.type.version | acceptedVersion | |
dc.identifier.scopus | 2-s2.0-85012257876 |