Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark
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AuthorsNovaković, Miroslav M.
Milosavljević, Slobodan M.
Article (Published version)
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Seven derivatives of pentacyclic triterpene acids (1-7) were isolated from the bark of Alnus viridis ssp. viridis using a combination of column chromatography and semipreparative HPLC. Compounds 1-3, 6, and 7 were determined to be new after spectroscopic data interpretation and were assigned as 27-hydroxyalphitolic acid derivatives (1-3), a 27-hydroxybetulinic acid derivative (6), and a 3-epi-maslinic acid derivative (7), respectively. Pentacyclic triterpenoids with a C-27 hydroxymethyl group have been found in species of the genus Alnus for the first time. These compounds were subjected to cytotoxicity testing against a number of canter cell lines. Also, selected pentacyclic triterpenoids were selected as potential inhibitors of topoisomerases I and Ha for an in silico investigation.
Source:Journal of Natural Products, 2017, 80, 5, 1255-1263
- Amer Chemical Soc, Washington
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
- Microbial diversity study and characterization of beneficial environmental microorganisms (RS-173048)
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3088