Synthesis of Natural Products and the Development of Synthetic Methodology: The Case Study of (-)-Atrop-abyssomicin C
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During our attempt to follow the planned synthetic route to the naturally occurring antibiotic (-)-atrop-abyssomicin C, we encountered two shortcomings, which forced us to reconsider our tactics and find new methods to overcome the problems. These methods turned out to be of general applicability, as demonstrated later in total syntheses of two other natural products: (+)-allokainic acid and (-)-gabosine H. The paper provides a brief account of these endeavors.
Keywords:
Abyssomicin C / Kainic acids / Gabosine / Natural products / Total synthesis / Synthetic methodsSource:
Natural Product Communications, 2017, 12, 8, 1209-1214Publisher:
- Natural Products Inc, Westerville
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Bihelović, Filip AU - Vulović, Bojan AU - Saičić, Radomir PY - 2017 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2512 AB - During our attempt to follow the planned synthetic route to the naturally occurring antibiotic (-)-atrop-abyssomicin C, we encountered two shortcomings, which forced us to reconsider our tactics and find new methods to overcome the problems. These methods turned out to be of general applicability, as demonstrated later in total syntheses of two other natural products: (+)-allokainic acid and (-)-gabosine H. The paper provides a brief account of these endeavors. PB - Natural Products Inc, Westerville T2 - Natural Product Communications T1 - Synthesis of Natural Products and the Development of Synthetic Methodology: The Case Study of (-)-Atrop-abyssomicin C VL - 12 IS - 8 SP - 1209 EP - 1214 UR - https://hdl.handle.net/21.15107/rcub_cherry_2512 ER -
@article{ author = "Bihelović, Filip and Vulović, Bojan and Saičić, Radomir", year = "2017", abstract = "During our attempt to follow the planned synthetic route to the naturally occurring antibiotic (-)-atrop-abyssomicin C, we encountered two shortcomings, which forced us to reconsider our tactics and find new methods to overcome the problems. These methods turned out to be of general applicability, as demonstrated later in total syntheses of two other natural products: (+)-allokainic acid and (-)-gabosine H. The paper provides a brief account of these endeavors.", publisher = "Natural Products Inc, Westerville", journal = "Natural Product Communications", title = "Synthesis of Natural Products and the Development of Synthetic Methodology: The Case Study of (-)-Atrop-abyssomicin C", volume = "12", number = "8", pages = "1209-1214", url = "https://hdl.handle.net/21.15107/rcub_cherry_2512" }
Bihelović, F., Vulović, B.,& Saičić, R.. (2017). Synthesis of Natural Products and the Development of Synthetic Methodology: The Case Study of (-)-Atrop-abyssomicin C. in Natural Product Communications Natural Products Inc, Westerville., 12(8), 1209-1214. https://hdl.handle.net/21.15107/rcub_cherry_2512
Bihelović F, Vulović B, Saičić R. Synthesis of Natural Products and the Development of Synthetic Methodology: The Case Study of (-)-Atrop-abyssomicin C. in Natural Product Communications. 2017;12(8):1209-1214. https://hdl.handle.net/21.15107/rcub_cherry_2512 .
Bihelović, Filip, Vulović, Bojan, Saičić, Radomir, "Synthesis of Natural Products and the Development of Synthetic Methodology: The Case Study of (-)-Atrop-abyssomicin C" in Natural Product Communications, 12, no. 8 (2017):1209-1214, https://hdl.handle.net/21.15107/rcub_cherry_2512 .