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dc.creatorJevtic, Bojan
dc.creatorDjedovic, Neda
dc.creatorStanisavljevic, Suzana
dc.creatorGašić, Uroš M.
dc.creatorMišić, Danijela
dc.creatorDespotovic, Jovana
dc.creatorSamardžić, Jelena
dc.creatorMiljkovic, Djordje
dc.creatorTimotijević, Gordana
dc.date.accessioned2018-11-22T00:41:20Z
dc.date.available2018-11-22T00:41:20Z
dc.date.issued2017
dc.identifier.issn1756-4646
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/2537
dc.description.abstractCucumber (Cucumis sativus) fruit has been used in cuisine worldwide, while its leaves are rich in immunomodulatory compounds. Cucumber leaf extract (CLE) was characterized by the predominance of triterpenoids cucurbitacins and significant levels of phenolics. Effects of CLE on CD4(+) T helper (Th) cells and macrophages, as the major encephalitogenic cells in the autoimmunity of the central nervous system were investigated in our study. CLE potently inhibited production of major pathogenic Th cytokines: interferon-gamma and interleukin-17, as well as of nitric oxide and reactive oxygen species in macrophages. Antigen-presenting activity of macrophages and dendritic cells was also affected by CLE. The effects of CLE were co-incident with modulation of NFKB and p38 MAPK signaling. Concentrations of CLE used in vitro did not show toxic effects on zebrafish embryos. Moreover, CLE inhibited generation of encephalitogenic cells in vivo. These results demonstrate that CLE deserve further investigation on its anti-encephalitogenic therapeutic properties. (C) 2017 Elsevier Ltd. All rights reserved.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172017/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173005/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173008/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173024/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173035/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Functional Foods
dc.subjectCucumberen
dc.subjectCucurbitacinen
dc.subjectT cellen
dc.subjectMacrophageen
dc.subjectAutoimmunityen
dc.subjectExperimental autoimmune encephalomyelitisen
dc.titleAnti-encephalitogenic effects of cucumber leaf extracten
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТимотијевиц, Гордана; Самардзиц, Јелена; Јевтиц, Бојан; Миљковиц, Дјордје; Гашић, Урош М.; Мисиц, Данијела; Дједовиц, Неда; Станисављевиц, Сузана; Деспотовиц, Јована;
dc.citation.volume37
dc.citation.spage249
dc.citation.epage262
dc.identifier.wos000412863400025
dc.identifier.doi10.1016/j.jff.2017.07.060
dc.citation.other37: 249-262
dc.citation.rankM21
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85026788295
dc.identifier.rcubKon_3353


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