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dc.creatorBožić, Bojana
dc.creatorKorać, Jelena
dc.creatorStanković, Dalibor
dc.creatorStanić, Marina
dc.creatorPopović-Bijelić, Ana
dc.creatorPristov-Bogdanović, Jelena
dc.creatorSpasojević, Ivan
dc.creatorBajčetić, Milica
dc.date.accessioned2018-11-22T00:41:48Z
dc.date.available2018-11-22T00:41:48Z
dc.date.issued2017
dc.identifier.issn0009-2797
dc.identifier.urihttps://cherry.chem.bg.ac.rs/handle/123456789/2570
dc.description.abstractToxic effects of unconjugated bilirubin (BR) in neonatal hyperbilirubinemia have been related to redox and/or coordinate interactions with Cu2+. However, the development and mechanisms of such interactions at physiological pH have not been resolved. This study shows that BR reduces Cu2+ to Cu1+ in 1:1 stoichiometry. Apparently, BR undergoes degradation, i.e. BR and Cu2+ do not form stable complexes. The binding of Cu2+ to inorganic phosphates, liposomal phosphate groups, or to chelating drug penicillamine, impedes redox interactions with BR. Cu1+ undergoes spontaneous oxidation by O-2 resulting in hydrogen peroxide accumulation and hydroxyl radical production. In relation to this, copper and BR induced synergistic oxidative/damaging effects on erythrocytes membrane, which were alleviated by penicillamine. The production of reactive oxygen species by BR and copper represents a plausible cause of BR toxic effects and cell damage in hyperbilirubinemia. Further examination of therapeutic potentials of copper chelators in the treatment of severe neonatal hyperbilirubinemia is needed.en
dc.publisherElsevier Ireland Ltd, Clare
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173017/RS//
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/621375/EU//
dc.rightsrestrictedAccess
dc.sourceChemico-biological Interactions
dc.subjectErythrocytesen
dc.subjectHydrogen peroxideen
dc.subjectHyperbilirubinemiaen
dc.subjectLipid peroxidationen
dc.subjectSuperoxideen
dc.titleMechanisms of redox interactions of bilirubin with copper and the effects of penicillamineen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтанковић, Далибор; Станиц, Марина; Пристов, Јелена Богдановиц; Корац, Јелена; Бозиц, Бојана; Спасојевиц, Иван; Поповиц-Бијелиц, Aна; Бајцетиц, Милица;
dc.citation.volume278
dc.citation.spage129
dc.citation.epage134
dc.identifier.wos000418302000016
dc.identifier.doi10.1016/j.cbi.2017.10.022
dc.citation.other278: 129-134
dc.citation.rankM21
dc.identifier.pmid29079291
dc.description.otherPeer-reviewed manuscript: [http://cherry.chem.bg.ac.rs/handle/123456789/3105]
dc.description.otherSupplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3106]
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-85032258652
dc.identifier.rcubKon_3386


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