Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity
AuthorsTodorović, Nevena M.
Šolaja, Bogdan A.
Article (Published version)
MetadataShow full item record
Cholestane-derived gem-dihydroperoxides and tetraoxanes were synthesized starting from 5 alpha- and 5 beta-cholestan-3-ones by acid-catalyzed addition of hydrogen peroxide to the ketone. They were characterized by IR, NMR, and mass spectroscopy analysis aided by molecular mechanics calculations, and, in the instance of 5 beta-cholestane-3 alpha,3 beta-dihydroperoxide (6), by x-ray analysis. The synthesized compounds were tested in vitro against Plasmodium falciparum Sierra Leone (D6) and Indochina (W2) malaria clones. All compounds were inactive to both clones, with the exception of tetraoxane 7a, which exhibited modest activity toward D6 clone with IC50 = 155 nM. (C) 1996 by Elsevier Science Inc.
Keywords:gem-dihydroperoxide / peroxide / tetraoxane / molecular mechanics / antimalarial activity
Source:Steroids, 1996, 61, 12, 688-696
- Elsevier Science Inc, New York