The synthesis and biological evaluation of A-ring substituted steroidal p-quinones
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The preparation of A-ring steroidal 1,4-quinones involves m-CPBA/(BzO)(2)O/hv oxidation of estrone (or estradiol 17-acetate), acid rearrangement of the obtained quinol, and oxidation A detailed NMR analysis of 1,4-quinones and their derivatives, as well as the results of preliminary antibacterial and cytotoxicity tests is presented. (C) 1997 Elsevier Science Ltd.
Source:Tetrahedron, 1997, 53, 41, 14073-14084
- Pergamon-Elsevier Science Ltd, Oxford