One-pot synthesis of biocompatible NaYF4:Yb,Er nanoparticles for cell labeling
Milošević, Olivera B.
ContributorsUskoković, Dragan P.
Radmilović, Velimir R.
Conference object (Published version)
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In modern medical research, great attention has been focused to the development of the new biomarkers which include up-converting nanoparticles (UCNPs). Their optical response is triggered by NIR radiation that achieves deeper tissue penetration when compared with traditionally used fluorophores. In this work, biocompatible NaYF4: Yb, Er nanoparticles were synthesized by polymer assisted one-pot solvothermal processing using chitosan or poly(lacticco- glycolic acid). X-ray powder diffraction and electron microscopy results revealed differences in crystal arrangement and morphology of the as-synthesized particles. Fourier transform infrared spectroscopy confirmed the presence of corresponding polymers moiety on UCNPs surface providing their biocompatibility and low cytotoxicity towards human gingival fibroblasts (HFG). As a consequence of efficient up-conversion, prominent green emission (between 512-533nm and between 533-560nm) as well as red emission (630-690nm) were recorded in the p...articles photoluminescence spectra, and these are applied further in the visualization of the HFG using the laser scanning microscopy with a NIR laser source.
Keywords:up-converting nanoparticles / NaYF4:Yb,Er / cell labelling / nanoparticles
Source:Programme and The Book of Abstracts / Twentieth Annual Conference YUCOMAT 2018, Herceg Novi, September 3-7, 2018, 2018, 116-116
- Belgrade : Materials Research Society of Serbia