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A new class of platinum(II) complexes with the phosphine ligand pta which show potent anticancer activity
(Royal Soc Chemistry, Cambridge, 2018)
The anticancer potential of sixteen platinum(II) complexes with general formulae [PtCl(hq)(S-dmso)] (1a-8a) and [PtCl(hq)(pta)] (1b-8b) (where hq is 5-chloro-7-iodo-8-quinolinol (clioquinol; cqH) (1a, 1b), 8-hydroxy-5-ni ...
Authentication of Turkish propolis through HPTLC fingerprints combined with multivariate analysis and palynological data and their comparative antioxidant activity
(Elsevier Science Bv, Amsterdam, 2018)
Propolis is a honeycomb product having very diverse chemical composition and possessing a broad spectrum of biological activities. This study comprehensively evaluated the phenolic profile of Turkish propolis by using a ...
Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity
(Elsevier, 2018)
An increase in the copper pool in body fluids has been related to a number of pathological conditions, including infections. Copper ions may affect antibiotics via the formation of coordination bonds and/or redox reactions. ...
Design, synthesis and biological evaluation of novel aryldiketo acids with enhanced antibacterial activity against multidrug resistant bacterial strains
(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2018)
Antimicrobial resistance (AMR) is a major health problem worldwide, because of ability of bacteria, fungi and viruses to evade known therapeutic agents used in treatment of infections. Aryldiketo acids (ADK) have shown ...
Newly designed hemagglutinin-Der p 2 chimera is a potential candidate for allergen specific immunotherapy
(Pergamon-Elsevier Science Ltd, Oxford, 2018)
Aim To investigate the immunomodulatory potential of a chimera composed of the receptor-binding domain of hemagglutinin 1 (H1s) from Influenza virus and Der p 2 (D2) allergen for allergen-specific immunotherapy of house-dust ...
The doping level of boron-doped diamond electrodes affects the voltammetric sensing ofuric acid
(Royal Soc Chemistry, Cambridge, 2018)
In this work, the electrochemical oxidation and subsequent determination of uric acid was investigated using boron-doped diamond electrodes with various B/C ratios (0-2000 ppm). The cyclic voltammetric study showed one ...
Insight into the Interactions of Amyloid -Sheets with Graphene Flakes: Scrutinizing the Role of Aromatic Residues in Amyloids that Interact with Graphene
(Wiley-V C H Verlag Gmbh, Weinheim, 2018)
The interaction of amyloid -sheet segments with graphene-flake models is investigated by using DFT calculations. The structure of -sheets of selected amyloid segments is based on crystal structures obtained from the Protein ...
Development of GFP-based high-throughput screening system for directed evolution of glucose oxidase
(Elsevier, 2018)
Glucose oxidase (GOx) mutants with higher activity or stability have important role in industry and in the development of biosensors and biofuel cells. Discovering these mutants can be time-consuming if appropriate ...
Streptomyces spp. in the biocatalysis toolbox
(Springer, New York, 2018)
About 20,100 research publications dated 2000-2017 were recovered searching the PubMed and Web of Science databases for Streptomyces, which are the richest known source of bioactive molecules. However, these bacteria with ...
Potential of natural-based anticancer compounds for P-glycoprotein inhibition
(Bentham Science Publishers B.V., 2018)
Medicinal value of natural products comes from symbiotic and competitive evolution in Earth’s complex biosphere. Billions of years of co-evolutionary interactions among millions of species have produced a large repertoire ...