Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae
AutoriTrifunović, Snežana S.
Isaković, Anđelka M.
Isaković, Aleksandra J.
Vučković, Ivan M.
Novaković, Miroslav M.
Milosavljević, Slobodan M.
Trajković, Vladimir S.
Članak u časopisu (Recenzirana verzija)
MetapodaciPrikaz svih podataka o dokumentu
Further phytochemical investigation into the aerial parts of Achillea clavennae has resulted in the 3 isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and 4 the iso-seco-guaianolide, 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known 5 compounds were also found in this plant species, of which 9 α -acetoxycanin (5), sintenin (6) and 6 oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were 7 elucidated by combined spectroscopic methods (1D and 2D NMR, HRESIMS, CIMS, FTIR). 8 While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-9 seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone 10 apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.
Ključne reči:Chemosystematics / Natural Products
Izvor:Planta medica, 2014, 80, 4, 275-305
- Georg Thieme Verlag