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dc.creatorTrifunović, Snežana S.
dc.creatorIsaković, Anđelka M.
dc.creatorIsaković, Aleksandra J.
dc.creatorVučković, Ivan M.
dc.creatorMandić, Boris
dc.creatorNovaković, Miroslav M.
dc.creatorVajs, Vlatka
dc.creatorMilosavljević, Slobodan M.
dc.creatorTrajković, Vladimir S.
dc.date.accessioned2019-02-01T10:25:10Z
dc.date.available2015-01-02
dc.date.issued2014
dc.identifier.issn0032-0943
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/2816
dc.description.abstractFurther phytochemical investigation into the aerial parts of Achillea clavennae has resulted in the 3 isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and 4 the iso-seco-guaianolide, 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known 5 compounds were also found in this plant species, of which 9 α -acetoxycanin (5), sintenin (6) and 6 oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were 7 elucidated by combined spectroscopic methods (1D and 2D NMR, HRESIMS, CIMS, FTIR). 8 While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-9 seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone 10 apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.sr
dc.language.isoensr
dc.publisherGeorg Thieme Verlagsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//sr
dc.rightsembargoedAccesssr
dc.sourcePlanta medicasr
dc.subjectChemosystematicssr
dc.subjectNatural Productssr
dc.titleIsolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennaesr
dc.typearticlesr
dc.rights.licenseBY-NC-NDsr
dcterms.abstractТрајковић, Владимир; Мандић, Борис; Новаковић, Мирослав; Вајс, Влатка; Милосављевић, Слободан; Трифуновић, Снежана С.; Исаковић, Aнђелка; Исаковић, Aлександра; Вучковић, Иван;
dc.citation.volume80
dc.citation.issue4
dc.citation.spage275
dc.citation.epage305
dc.identifier.wos000332395000008
dc.identifier.doi10.1055/s-0033-1360312
dc.citation.rankM21~
dc.type.versionacceptedVersionsr
dc.identifier.scopus2-s2.0-84895928430
dc.identifier.fulltexthttp://cherry.chem.bg.ac.rs/bitstream/id/6458/manuscript.pdf


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