dc.creator | Trifunović, Snežana S. | |
dc.creator | Isaković, Anđelka M. | |
dc.creator | Isaković, Aleksandra J. | |
dc.creator | Vučković, Ivan M. | |
dc.creator | Mandić, Boris | |
dc.creator | Novaković, Miroslav M. | |
dc.creator | Vajs, Vlatka | |
dc.creator | Milosavljević, Slobodan M. | |
dc.creator | Trajković, Vladimir S. | |
dc.date.accessioned | 2019-02-01T10:25:10Z | |
dc.date.available | 2015-01-02 | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0032-0943 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/2816 | |
dc.description.abstract | Further phytochemical investigation into the aerial parts of Achillea clavennae has resulted in the 3
isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and 4
the iso-seco-guaianolide, 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known 5
compounds were also found in this plant species, of which 9 α -acetoxycanin (5), sintenin (6) and 6
oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were 7
elucidated by combined spectroscopic methods (1D and 2D NMR, HRESIMS, CIMS, FTIR). 8
While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-9
seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone 10
apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines. | sr |
dc.language.iso | en | sr |
dc.publisher | Georg Thieme Verlag | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | sr |
dc.rights | embargoedAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Planta medica | sr |
dc.subject | Chemosystematics | sr |
dc.subject | Natural Products | sr |
dc.title | Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae | sr |
dc.type | article | sr |
dc.rights.license | BY-NC-ND | sr |
dcterms.abstract | Трајковић, Владимир; Мандић, Борис; Новаковић, Мирослав; Вајс, Влатка; Милосављевић, Слободан; Трифуновић, Снежана С.; Исаковић, Aнђелка; Исаковић, Aлександра; Вучковић, Иван; | |
dc.citation.volume | 80 | |
dc.citation.issue | 4 | |
dc.citation.spage | 275 | |
dc.citation.epage | 305 | |
dc.identifier.wos | 000332395000008 | |
dc.identifier.doi | 10.1055/s-0033-1360312 | |
dc.citation.rank | M21 | |
dc.type.version | acceptedVersion | sr |
dc.identifier.scopus | 2-s2.0-84895928430 | |
dc.identifier.fulltext | https://cherry.chem.bg.ac.rs/bitstream/id/6458/manuscript.pdf | |