Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet
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This paper reports a droplet-based microfluidic approach to fabricate a large number of monodisperse, portable microtissues, each in an individual drop. We use water-water-oil double emulsions as templates and spatially assemble hepatocytes in the core and fibroblasts in the shell, forming a 3D liver model in a drop.
Source:
Lab on A Chip, 2016, 16, 8, 1346-1349Publisher:
- Royal Soc Chemistry, Cambridge
Funding / projects:
- National Science Foundation [DMR-1310266]
- China Equipment and Education Resources System [CERS-1-75]
- Harvard Materials Research Science and Engineering Center [DMR-1420570]
- National Institutes of Health [R01EB014703]
- Deutsche Forschungsgemeinschaft
- National Natural Science Foundation of China [214350002, 91213305, 81373373]
Note:
- This is the peer-reviewed version of the following article: Chen, Qiushui, Utech, Stefanie, Chen, Dong, Prodanović, Radivoje, Lin, Jin-Ming, Weitz, David A., 2016. Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet. Lab on A Chip. 16, 1346-1349. https://doi.org/10.1039/c6lc00231e
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3427
DOI: 10.1039/c6lc00231e
ISSN: 1473-0197
PubMed: 26999495
WoS: 000374224900006
Scopus: 2-s2.0-84964963468
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Chen, Qiushui AU - Utech, Stefanie AU - Chen, Dong AU - Prodanović, Radivoje AU - Lin, Jin-Ming AU - Weitz, David A. PY - 2016 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2820 AB - This paper reports a droplet-based microfluidic approach to fabricate a large number of monodisperse, portable microtissues, each in an individual drop. We use water-water-oil double emulsions as templates and spatially assemble hepatocytes in the core and fibroblasts in the shell, forming a 3D liver model in a drop. PB - Royal Soc Chemistry, Cambridge T2 - Lab on A Chip T1 - Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet VL - 16 IS - 8 SP - 1346 EP - 1349 DO - 10.1039/c6lc00231e ER -
@article{ author = "Chen, Qiushui and Utech, Stefanie and Chen, Dong and Prodanović, Radivoje and Lin, Jin-Ming and Weitz, David A.", year = "2016", abstract = "This paper reports a droplet-based microfluidic approach to fabricate a large number of monodisperse, portable microtissues, each in an individual drop. We use water-water-oil double emulsions as templates and spatially assemble hepatocytes in the core and fibroblasts in the shell, forming a 3D liver model in a drop.", publisher = "Royal Soc Chemistry, Cambridge", journal = "Lab on A Chip", title = "Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet", volume = "16", number = "8", pages = "1346-1349", doi = "10.1039/c6lc00231e" }
Chen, Q., Utech, S., Chen, D., Prodanović, R., Lin, J.,& Weitz, D. A.. (2016). Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet. in Lab on A Chip Royal Soc Chemistry, Cambridge., 16(8), 1346-1349. https://doi.org/10.1039/c6lc00231e
Chen Q, Utech S, Chen D, Prodanović R, Lin J, Weitz DA. Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet. in Lab on A Chip. 2016;16(8):1346-1349. doi:10.1039/c6lc00231e .
Chen, Qiushui, Utech, Stefanie, Chen, Dong, Prodanović, Radivoje, Lin, Jin-Ming, Weitz, David A., "Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet" in Lab on A Chip, 16, no. 8 (2016):1346-1349, https://doi.org/10.1039/c6lc00231e . .