Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet
Abstract
This paper reports a droplet-based microfluidic approach to fabricate a large number of monodisperse, portable microtissues, each in an individual drop. We use water-water-oil double emulsions as templates and spatially assemble hepatocytes in the core and fibroblasts in the shell, forming a 3D liver model in a drop.
Source:
Lab on A Chip, 2016, 16, 8, 1346-1349Publisher:
- Royal Soc Chemistry, Cambridge
Projects:
- National Science Foundation [DMR-1310266]
- China Equipment and Education Resources System [CERS-1-75]
- Harvard Materials Research Science and Engineering Center [DMR-1420570]
- National Institutes of Health [R01EB014703]
- Deutsche Forschungsgemeinschaft
- National Natural Science Foundation of China [214350002, 91213305, 81373373]
Note:
- This is the peer-reviewed version of the following article: Chen, Qiushui, Utech, Stefanie, Chen, Dong, Prodanović, Radivoje, Lin, Jin-Ming, Weitz, David A., 2016. Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet. Lab on A Chip. 16, 1346-1349. https://doi.org/10.1039/c6lc00231e
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3427
DOI: 10.1039/c6lc00231e
ISSN: 1473-0197
PubMed: 26999495
WoS: 000374224900006
Scopus: 2-s2.0-84964963468
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