Introducing of modeling techniques in the research of POPs in breast milk – A pilot study
Authorized Users Only
Herceg Romanić, Snježana
Matek Sarić, Marijana
Grzunov Letinić, Judita
Popović, Aleksandar R.
Article (Published version)
MetadataShow full item record
This study used advanced statistical and machine learning methods to investigate organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in breast milk, assuming that in a complex biological mixture, the pollutants emitted from the same source or with similar properties are statistically interrelated and possibly exhibit non-linear dynamics. The elaborated analyses such as Unmix source apportionment characterized individual source groups, while guided regularized random forest indicated the pollutant dependence on the ortho-chlorine atom attached to the congener's phenyl ring and mother's age. Mutual associations among PCBs were further discussed, but the results implied they were mostly not related to child delivery. PCB congeners −153, −180, −170, −118, −156, −105, and −138 appeared to be compounds of the outmost importance for mutual prediction with reference to their interrelations regarding chemical structure and metabolic processes in the mother's body. Finally, mac...hine learning methods, which provided prediction relative errors lower than 30% and correlation coefficients higher than 0.90, suggested a possible strong non-linear relationship among the pollutants and consequently, the complexity of their pathways in the breast milk.
Keywords:Age / Feature selection / Machine learning / Parity / Persistent organic pollutants (POPs) / Unmix
Source:Ecotoxicology and Environmental Safety, 2019, 172, 341-347
- Croatian Science Foundation (Project OPENTOX, No. 8366)
- Studying climate change and its influence on environment: impacts, adaptation and mitigation (RS-43007)
- Application of low temperature plasmas in biomedicine, environmental protection and nanotechnologies (RS-41011)