Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone
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AuthorsMeszaros, Janos P.
Gal, Tamas G.
May, Nora V.
Enyedy, Eva A.
Article (Accepted Version)
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Half-sandwich organometallic complexes of curcumin are extensively investigated as anticancer compounds.Speciation studies were performed to explore the solution stability of curcumin complexes formed with [Rh(η5- C5Me5)(H2O)3]2+. Acetylacetone (Hacac), as the simplest β-diketone ligand bearing (O,O) donor set, was involved for comparison and its Ru(η6‑p‑cymene), Ru(η6‑toluene) complexes were also studied. 1H NMR, UV–visible and pH-potentiometric titrations revealed a clear trend of stability constants of the acac complexes: Ru(η6‑p‑cymene) > Ru(η6‑toluene) > Rh(η5-C5Me5). Despite this order, the highest extent of complex formation is seen for the Rh(η5-C5Me5) complexes at pH 7.4. Formation constant of [Rh(η5-C5Me5)(H2curcumin) (H2O)]+ reveals similar solution stability to that of the acac complex. Additionally, structures of two complexes were determined by X-ray crystallography. The in vitro cytotoxicity of curcumin was not improved by the complexation with these organometallic catio...ns.
Keywords:Curcumin / Cytotoxicity / Half-sandwich complexes / Solution stability / X-ray crystal structures
Source:Journal of Inorganic Biochemistry, 2019, 195, 91-100
- National Research Development and Innovation Office-NKFIA through projects GINOP-2.3.2-15-2016-00038, FK 124240, K 115762
- Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT
- J. Bolyai Research Scholarship of the Hungarian Academy of Sciences (É.A.E, N.V.M.)
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/2875
- This is the peer-reviewed version of the following article: Meszaros, J. P.; Poljarević, J.; Gal, T. G.; May, N. V.; Spengler, G.; Enyedy, E. A. Comparative Solution and Structural Studies of Half-Sandwich Rhodium and Ruthenium Complexes Bearing Curcumin and Acetylacetone. Journal of Inorganic Biochemistry 2019, 195, 91–100. https://doi.org/10.1016/j.jinorgbio.2019.02.015