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Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone
| dc.creator | Meszaros, Janos P. | |
| dc.creator | Poljarević, Jelena | |
| dc.creator | Gal, Tamas G. | |
| dc.creator | May, Nora V. | |
| dc.creator | Spengler, Gabriella | |
| dc.creator | Enyedy, Eva A. | |
| dc.date.accessioned | 2019-04-15T16:01:52Z | |
| dc.date.available | 2021-02-26 | |
| dc.date.available | 2021-02-26 | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 0162-0134 | |
| dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/2891 | |
| dc.description.abstract | Half-sandwich organometallic complexes of curcumin are extensively investigated as anticancer compounds.Speciation studies were performed to explore the solution stability of curcumin complexes formed with [Rh(η5- C5Me5)(H2O)3]2+. Acetylacetone (Hacac), as the simplest β-diketone ligand bearing (O,O) donor set, was involved for comparison and its Ru(η6‑p‑cymene), Ru(η6‑toluene) complexes were also studied. 1H NMR, UV–visible and pH-potentiometric titrations revealed a clear trend of stability constants of the acac complexes: Ru(η6‑p‑cymene) > Ru(η6‑toluene) > Rh(η5-C5Me5). Despite this order, the highest extent of complex formation is seen for the Rh(η5-C5Me5) complexes at pH 7.4. Formation constant of [Rh(η5-C5Me5)(H2curcumin) (H2O)]+ reveals similar solution stability to that of the acac complex. Additionally, structures of two complexes were determined by X-ray crystallography. The in vitro cytotoxicity of curcumin was not improved by the complexation with these organometallic cations. | |
| dc.publisher | Elsevier | |
| dc.relation | National Research Development and Innovation Office-NKFIA through projects GINOP-2.3.2-15-2016-00038, FK 124240, K 115762 | |
| dc.relation | Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT | |
| dc.relation | J. Bolyai Research Scholarship of the Hungarian Academy of Sciences (É.A.E, N.V.M.) | |
| dc.rights | embargoedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.source | Journal of Inorganic Biochemistry | |
| dc.subject | Curcumin | |
| dc.subject | Cytotoxicity | |
| dc.subject | Half-sandwich complexes | |
| dc.subject | Solution stability | |
| dc.subject | X-ray crystal structures | |
| dc.title | Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone | |
| dc.type | article | |
| dc.rights.license | BY-NC-ND | |
| dcterms.abstract | Месзарос, Јанос П.; Гал, Тамас Г.; Маy, Нора В.; Спенглер, Габриелла; Енyедy, Ева A.; Пољаревић, Јелена; | |
| dc.citation.volume | 195 | |
| dc.citation.spage | 91 | |
| dc.citation.epage | 100 | |
| dc.identifier.wos | 000469408500010 | |
| dc.identifier.doi | 10.1016/j.jinorgbio.2019.02.015 | |
| dc.citation.rank | M21~ | |
| dc.description.other | Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/2875] | |
| dc.description.other | This is the peer-reviewed version of the following article: Meszaros, J. P.; Poljarević, J.; Gal, T. G.; May, N. V.; Spengler, G.; Enyedy, E. A. Comparative Solution and Structural Studies of Half-Sandwich Rhodium and Ruthenium Complexes Bearing Curcumin and Acetylacetone. Journal of Inorganic Biochemistry 2019, 195, 91–100. [https://doi.org/10.1016/j.jinorgbio.2019.02.015] | |
| dc.type.version | acceptedVersion | |
| dc.identifier.scopus | 2-s2.0-85063508269 | |
| dc.identifier.fulltext | https://cherry.chem.bg.ac.rs/bitstream/id/6698/10.1016@j.jinorgbio.2019.02.015.pdf |
