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dc.creatorPerić, Marko
dc.creatorRadović, Magdalena
dc.creatorMirković, Marija D
dc.creatorNikolić, Aleksandar S.
dc.creatorIskrenović, Predrag
dc.creatorJanković, Drina
dc.creatorVranješ-Đurić, Sanja
dc.date.accessioned2019-04-22T10:19:52Z
dc.date.available2019-04-22T10:19:52Z
dc.date.issued2019
dc.identifier.issn1144-0546
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/2910
dc.description.abstractThe advances in nanotechnology are directed towards the development of new theranostic agents based on magnetic nanoparticles that can be used for both cancer detection and treatment. In this study, 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles (Fe 3 O 4 -DPD MNPs) were evaluated for their theranostic application using different methods. The magnetic hyperthermia efficiency of the Fe 3 O 4 -DPD MNPs was investigated in saline solution with ionic strengths between 0.05 and 1.0 mol dm −3 . For a better understanding of hyperthermia, the behavior of Fe 3 O 4 -DPD MNPs under a non-alternating magnetic field was studied, and the transparency of the sample was measured. Furthermore, the radiotracer method using the radionuclides 99m Tc and 90 Y was applied as a reliable and powerful method for evaluating the in vivo behavior of a nanoprobe; a high radiolabeling yield (>93%), in vitro and in vivo stability of the radiolabeled nanoparticles and high heating effect were observed, thus paving the way for the possible theranostic applications of Fe 3 O 4 -DPD MNPs.
dc.publisherThe Royal Society of Chemistry
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45015/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/171034/RS//
dc.rightsrestrictedAccess
dc.sourceNew Journal of Chemistry
dc.titleThe analysis of 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles under an external magnetic field and their radiolabeling for possible theranostic applications
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНиколић, Aлександар С.; Перић, Марко; Радовић, Магдалена; Мирковић, Марија Д; Искреновић, Предраг; Јанковић, Дрина; Врањеш-Ђурић, Сања;
dc.citation.volume43
dc.citation.issue15
dc.citation.spage5932
dc.citation.epage5939
dc.identifier.wos000465240500031
dc.identifier.doi10.1039/c8nj06478d
dc.citation.rankM22~
dc.description.otherPeer-reviewed manuscript: [http://cherry.chem.bg.ac.rs/handle/123456789/2911]
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85064107332


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