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dc.creatorOzek, Gulmira
dc.creatorYur, Suleyman
dc.creatorGoger, Fatih
dc.creatorOzek, Temel
dc.creatorAnđelković, Boban D.
dc.creatorGodjevac, Dejan
dc.creatorSofrenić, Ivana V.
dc.creatorAneva, Ina
dc.creatorTodorova, Milka
dc.creatorTrendafilova, Antoaneta
dc.date.accessioned2019-05-08T09:49:39Z
dc.date.available2019-05-08T09:49:39Z
dc.date.issued2019
dc.identifier.issn1612-1872
dc.identifier.urihttps://cherry.chem.bg.ac.rs/handle/123456789/2922
dc.description.abstractHexane extracts of Heracleum verticillatum, H. sibiricum, H. angustisectum, and H. ternatum were studied for their furanocoumarin content antioxidant potential and acetylcholinesterase and α-amylase inhibitory activities. Quantification of the furanocoumarins was performed by 1 H-NMR. Pimpinellin was found to be the main component in the roots of all studied species. Bergapten and imperatorin were the major compounds in the fruits of H. sibiricum and H. verticillatum, respectively, while byakangelicol dominated in H. angustisectum and H. ternatum fruits. The leaf and fruit extracts of H. angustisectum demonstrated the highest DPPH radical scavenging activity and TEAC (IC 50 0.58 mg/mL and 1.83 mm, respectively). The root extracts of H. verticillatum and H. angustisectum were found to be the most effective against acetylcholinesterase (IC 50 0.30 and 0.34 mg/mL, respectively). The studied extracts were not active or demonstrated a weak inhibitory effect (%Inh. up to 29.7) towards α-amylase.
dc.publisherWiley-VHCA AG
dc.rightsrestrictedAccess
dc.sourceChemistry and Biodiversity
dc.subjectacetylcholinesterase inhibition
dc.subjectantidiabetic activity
dc.subjectantioxidants
dc.subjectfuranocoumarins
dc.subjectHeracleum species
dc.titleFuranocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer's Disease and Type II Diabetes
dc.typearticle
dc.rights.licenseARR
dcterms.abstractОзек, Гулмира; Yур, Сулеyман; Гогер, Фатих; Озек, Темел; Aндјелковић, Бобан; Годјевац, Дејан; Софренић, Ивана В.; Aнева, Ина; Тодорова, Милка; Трендафилова, Aнтоанета;
dc.citation.volume16
dc.citation.issue4
dc.citation.spage1800672
dc.identifier.wos000467184500017
dc.identifier.doi10.1002/cbdv.201800672
dc.citation.rankM22~
dc.description.otherPeer-reviewed manuscript: [http://cherry.chem.bg.ac.rs/handle/123456789/2923]
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85063580781


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