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Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer's Disease and Type II Diabetes

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Furanocoumarin_Content_Antioxidant_acc_2019.pdf (4.395Mb)
Authors
Ozek, Gulmira
Yur, Suleyman
Goger, Fatih
Ozek, Temel
Anđelković, Boban D.
Godjevac, Dejan
Sofrenić, Ivana V.
Aneva, Ina
Todorova, Milka
Trendafilova, Antoaneta
Article (Accepted Version)
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Abstract
Hexane extracts of Heracleum verticillatum, H. sibiricum, H. angustisectum, and H. ternatum were studied for their furanocoumarin content antioxidant potential and acetylcholinesterase and α-amylase inhibitory activities. Quantification of the furanocoumarins was performed by 1 H-NMR. Pimpinellin was found to be the main component in the roots of all studied species. Bergapten and imperatorin were the major compounds in the fruits of H. sibiricum and H. verticillatum, respectively, while byakangelicol dominated in H. angustisectum and H. ternatum fruits. The leaf and fruit extracts of H. angustisectum demonstrated the highest DPPH radical scavenging activity and TEAC (IC 50 0.58 mg/mL and 1.83 mm, respectively). The root extracts of H. verticillatum and H. angustisectum were found to be the most effective against acetylcholinesterase (IC 50 0.30 and 0.34 mg/mL, respectively). The studied extracts were not active or demonstrated a weak inhibitory effect (%Inh. up to 29.7) towards α-amyl...ase.

Keywords:
acetylcholinesterase inhibition / antidiabetic activity / antioxidants / furanocoumarins / Heracleum species
Source:
Chemistry and Biodiversity, 2019, 16, 4, 1800672-
Publisher:
  • Wiley-VHCA AG
Note:
  • This is the peer-reviewed version of the following article:Ozek, G.; Yur, S.; Goger, F.; Ozek, T.; Andjelkovic, B.; Godjevac, D.; Sofrenic, I.; Aneva, I.; Todorova, M.; Trendafilova, A. Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum Verticillatum, Heracleum Sibiricum, Heracleum Angustisectum, and Heracleum Ternatum Extracts against Enzymes Involved in Alzheimer’s Disease and Type II Diabetes. Chemistry and Biodiversity 2019, 16 (4). https://doi.org/10.1002/cbdv.201800672.

DOI: 10.1002/cbdv.201800672

ISSN: 1612-1872

WoS: 000467184500017

Scopus: 2-s2.0-85063580781
[ Google Scholar ]
15
5
URI
https://cherry.chem.bg.ac.rs/handle/123456789/2923
Collections
  • Publikacije / Publications
Institution/Community
Hemijski fakultet / Faculty of Chemistry
TY  - JOUR
AU  - Ozek, Gulmira
AU  - Yur, Suleyman
AU  - Goger, Fatih
AU  - Ozek, Temel
AU  - Anđelković, Boban D.
AU  - Godjevac, Dejan
AU  - Sofrenić, Ivana V.
AU  - Aneva, Ina
AU  - Todorova, Milka
AU  - Trendafilova, Antoaneta
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2923
AB  - Hexane extracts of Heracleum verticillatum, H. sibiricum, H. angustisectum, and H. ternatum were studied for their furanocoumarin content antioxidant potential and acetylcholinesterase and α-amylase inhibitory activities. Quantification of the furanocoumarins was performed by 1 H-NMR. Pimpinellin was found to be the main component in the roots of all studied species. Bergapten and imperatorin were the major compounds in the fruits of H. sibiricum and H. verticillatum, respectively, while byakangelicol dominated in H. angustisectum and H. ternatum fruits. The leaf and fruit extracts of H. angustisectum demonstrated the highest DPPH radical scavenging activity and TEAC (IC 50 0.58 mg/mL and 1.83 mm, respectively). The root extracts of H. verticillatum and H. angustisectum were found to be the most effective against acetylcholinesterase (IC 50 0.30 and 0.34 mg/mL, respectively). The studied extracts were not active or demonstrated a weak inhibitory effect (%Inh. up to 29.7) towards α-amylase.
PB  - Wiley-VHCA AG
T2  - Chemistry and Biodiversity
T1  - Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer's Disease and Type II Diabetes
VL  - 16
IS  - 4
SP  - 1800672
DO  - 10.1002/cbdv.201800672
ER  - 
@article{
author = "Ozek, Gulmira and Yur, Suleyman and Goger, Fatih and Ozek, Temel and Anđelković, Boban D. and Godjevac, Dejan and Sofrenić, Ivana V. and Aneva, Ina and Todorova, Milka and Trendafilova, Antoaneta",
year = "2019",
abstract = "Hexane extracts of Heracleum verticillatum, H. sibiricum, H. angustisectum, and H. ternatum were studied for their furanocoumarin content antioxidant potential and acetylcholinesterase and α-amylase inhibitory activities. Quantification of the furanocoumarins was performed by 1 H-NMR. Pimpinellin was found to be the main component in the roots of all studied species. Bergapten and imperatorin were the major compounds in the fruits of H. sibiricum and H. verticillatum, respectively, while byakangelicol dominated in H. angustisectum and H. ternatum fruits. The leaf and fruit extracts of H. angustisectum demonstrated the highest DPPH radical scavenging activity and TEAC (IC 50 0.58 mg/mL and 1.83 mm, respectively). The root extracts of H. verticillatum and H. angustisectum were found to be the most effective against acetylcholinesterase (IC 50 0.30 and 0.34 mg/mL, respectively). The studied extracts were not active or demonstrated a weak inhibitory effect (%Inh. up to 29.7) towards α-amylase.",
publisher = "Wiley-VHCA AG",
journal = "Chemistry and Biodiversity",
title = "Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer's Disease and Type II Diabetes",
volume = "16",
number = "4",
pages = "1800672",
doi = "10.1002/cbdv.201800672"
}
Ozek, G., Yur, S., Goger, F., Ozek, T., Anđelković, B. D., Godjevac, D., Sofrenić, I. V., Aneva, I., Todorova, M.,& Trendafilova, A.. (2019). Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer's Disease and Type II Diabetes. in Chemistry and Biodiversity
Wiley-VHCA AG., 16(4), 1800672.
https://doi.org/10.1002/cbdv.201800672
Ozek G, Yur S, Goger F, Ozek T, Anđelković BD, Godjevac D, Sofrenić IV, Aneva I, Todorova M, Trendafilova A. Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer's Disease and Type II Diabetes. in Chemistry and Biodiversity. 2019;16(4):1800672.
doi:10.1002/cbdv.201800672 .
Ozek, Gulmira, Yur, Suleyman, Goger, Fatih, Ozek, Temel, Anđelković, Boban D., Godjevac, Dejan, Sofrenić, Ivana V., Aneva, Ina, Todorova, Milka, Trendafilova, Antoaneta, "Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer's Disease and Type II Diabetes" in Chemistry and Biodiversity, 16, no. 4 (2019):1800672,
https://doi.org/10.1002/cbdv.201800672 . .

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