Benzothiazole carbamates and amides as antiproliferative species
Authors
Selaković, Milica
Mojsin, Marija
Stevanović, Milena
Opsenica, Igor
Srdić-Rajić, Tatjana
Šolaja, Bogdan A.
Article (Accepted Version)
Metadata
Show full item recordAbstract
A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, sub-micromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness. (C) 2018 Elsevier Masson SAS. All rights reserved.
Keywords:
Benzothiazoles / Antiproliferative / MCF-7 / NT2/D1 / AnoikisSource:
European Journal of Medicinal Chemistry, 2018, 157, 1096-1114Publisher:
- Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
Projects:
- The synthesis of aminoquinoline-based antimalarials and botulinum neurotoxin A inhibitors (RS-172008)
- Studying signal transduction pathways and epigenetic mechanisms that control human SOX genes expression: further insight into their roles in cell fate determination and differentiation (RS-173051)
- Serbian Academy of Sciences and Arts
Note:
- This is the peer-reviewed version of the following article: Videnović, M.; Mojsin, M.; Stevanović, M.; Opsenica, I.; Srdić-Rajić, T.; Šolaja, B. Benzothiazole Carbamates and Amides as Antiproliferative Species. Eur. J. Med. Chem. 2018, 157, 1096–1114. https://doi.org/10.1016/j.ejmech.2018.08.067
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/2961
DOI: 10.1016/j.ejmech.2018.08.067
ISSN: 0223-5234
PubMed: 30179747
WoS: 000447480000079
Scopus: 2-s2.0-85054063702
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