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Benzothiazole carbamates and amides as antiproliferative species
| dc.creator | Videnović, Milica | |
| dc.creator | Mojsin, Marija | |
| dc.creator | Stevanović, Milena | |
| dc.creator | Opsenica, Igor | |
| dc.creator | Srdić-Rajić, Tatjana | |
| dc.creator | Šolaja, Bogdan A. | |
| dc.date.accessioned | 2019-05-16T12:14:07Z | |
| dc.date.available | 2020-08-25 | |
| dc.date.issued | 2018 | |
| dc.identifier.issn | 0223-5234 | |
| dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/2960 | |
| dc.description.abstract | A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, sub-micromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness. (C) 2018 Elsevier Masson SAS. All rights reserved. | en |
| dc.publisher | Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux | |
| dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172008/RS// | |
| dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173051/RS// | |
| dc.relation | Serbian Academy of Sciences and Arts | |
| dc.rights | embargoedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.source | European Journal of Medicinal Chemistry | |
| dc.subject | Benzothiazoles | en |
| dc.subject | Antiproliferative | en |
| dc.subject | MCF-7 | en |
| dc.subject | NT2/D1 | en |
| dc.subject | Anoikis | en |
| dc.title | Benzothiazole carbamates and amides as antiproliferative species | en |
| dc.type | article | |
| dc.rights.license | BY-NC-ND | |
| dcterms.abstract | Срдиц-Рајиц, Татјана; Шолаја, Богдан A.; Стевановиц, Милена; Селаковић, Милица; Опсеница, Игор; Мојсин, Марија; | |
| dc.citation.volume | 157 | |
| dc.citation.spage | 1096 | |
| dc.citation.epage | 1114 | |
| dc.identifier.wos | 000447480000079 | |
| dc.identifier.doi | 10.1016/j.ejmech.2018.08.067 | |
| dc.citation.other | 157: 1096-1114 | |
| dc.citation.rank | aM21 | |
| dc.identifier.pmid | 30179747 | |
| dc.description.other | This is the peer-reviewed version of the following article: Videnović, M.; Mojsin, M.; Stevanović, M.; Opsenica, I.; Srdić-Rajić, T.; Šolaja, B. Benzothiazole Carbamates and Amides as Antiproliferative Species. Eur. J. Med. Chem. 2018, 157, 1096–1114. [https://doi.org/10.1016/j.ejmech.2018.08.067] | |
| dc.description.other | Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/2961] | |
| dc.type.version | acceptedVersion | en |
| dc.identifier.scopus | 2-s2.0-85054063702 | |
| dc.identifier.fulltext | https://cherry.chem.bg.ac.rs/bitstream/id/6940/10.1016@j.ejmech.2018.08.067.pdf |
