Show simple item record

dc.creatorSamiec, Petr
dc.creatorŠovrc, Ľubomír
dc.creatorStanković, Dalibor
dc.creatorVojs, Marian
dc.creatorMarton, Marian
dc.creatorNavrátilová, Zuzana
dc.date.accessioned2019-06-03T16:26:22Z
dc.date.available2018-02-02
dc.date.issued2017
dc.identifier.issn0925-4005
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/3080
dc.description.abstractThe boron-doped diamond electrodes (BDDEs) with different dopant levels were applied as advanced, mercury-free and modification-free electroanalytical platforms for simple and reliable quantification of benzodiazepines, bromazepam (BZ) and alprazolam (ALZ). Cyclic voltammetric measurements revealed that the electrode reactions of both analytes were manifested by one irreversible and diffusion-controlled reduction peak at -1.10V in Britton-Robinson buffer of pH 11 for BZ using lab-made BDDE with 1000 ppm B/C ratio and -0.84V in BR buffer of pH 5 for ALZ using commercial BDDE with 1000 ppm B/C ratio. Differential pulse voltammetry was used for construction of calibration curves for BZ and ALZ, respectively, with the analytical parameters as follows: the linear dynamic ranges of 1 x 10(-6)-1 x 10(-4) and 8 x 10(-7)-1 x 10(-4) mol/L, the detection limit of 3.1 x 10(-7) and 6.4 x 10(-7) mol/L and the excellent repeatability with the relative standard deviation below 3% for both drugs. The developed methods were applied to analysis of the pharmaceutical tablets with the recoveries from 97.33 to 100.85% for BZ and from 94.14 to 101.32% for ALZ. The usage of BDDEs as advanced electrochemical sensors in drug analysis represents a facile and effective analytical approach which may replace mercury-based sensors and chemically modified electrodes in previous benzodiazepines sensing.
dc.publisherElsevier Science Sa, Lausanne
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172030/RS//
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/621375/EU//
dc.relationSTU Grant scheme
dc.relationStudent grant competition (University of Ostrava) [SGS07/PrF/2015, SGS03/PrF/2016]
dc.relationGrant Agency of the Slovak Republic [1/0489/16]
dc.relationSlovak Research and Development Agency [APVV-0365-12]
dc.rightsembargoedAccess
dc.sourceSensors and Actuators, B: Chemical
dc.subjectBenzodiazepines
dc.subjectBoron-doped diamond electrode
dc.subjectDifferential pulse voltammetry
dc.subjectElectrochemical sensor
dc.subjectPharmaceutical tablet
dc.titleMercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractСамиец, Петр; Шоврц, Ľубомíр; Станковић, Далибор; Војс, Мариан; Мартон, Мариан; Наврáтиловá, Зузана;
dc.citation.volume245
dc.citation.spage963
dc.citation.epage971
dc.identifier.wos000398760700113
dc.identifier.doi10.1016/j.snb.2017.02.023
dc.citation.rankM21
dc.description.otherThis is the peer-reviewed version of the following article: Samiec, P.; Švorc, Ľ.; Stanković, D. M.; Vojs, M.; Marton, M.; Navrátilová, Z. Mercury-Free and Modification-Free Electroanalytical Approach towards Bromazepam and Alprazolam Sensing: A Facile and Efficient Assay for Their Quantification in Pharmaceuticals Using Boron-Doped Diamond Electrodes. Sensors and Actuators, B: Chemical 2017, 245, 963–971. [https://doi.org/10.1016/j.snb.2017.02.023]
dc.description.otherSupplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3081]
dc.type.versionacceptedVersion
dc.identifier.scopus2-s2.0-85013001578
dc.identifier.fulltexthttp://cherry.chem.bg.ac.rs/bitstream/id/7381/samiec2017.pdf


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record