Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study
Samo za registrovane korisnike
2019
Autori
Filipović, Nenad R.Ristić, Predrag
Janjić, Goran V.
Klisurić, Olivera
Puerta, A.
Padrón, José M.
Donnard, Morgan
Gulea, Mihaela
Todorović, Tamara
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The first complexes of 2-pyridylthiocyanate (L) and silver nitrate (1) and perchlorate (2) were prepared and characterized by a single crystal X-ray analysis. The common structural motif of both 1 and 2 is coordination of two L molecules via pyridine nitrogen atom to Ag(I). In order to properly describe the nature of coordinative bonds in 1 and 2, as well as crystal packings in respective structures, a Quantum Theory of Atoms in Molecule topological analysis was performed. Coordinated nitrate ion provides more electron density to Ag(I) in comparison to perchlorate ion. Additional electron density in the case of 2 was provided by the coordination of third L molecule via thiocyanate nitrogen atom resulting in a 1D polymeric structure. Detailed computational analysis of intermolecular interactions, as well analysis of interactions between pyridine ring and –SCN group was performed. Antiproliferative activity of monomeric compound 1 was found to be better than of cisplatin on three out of ...four studied human cancer cell lines. Docking studies indicate intercalation as a major binding mode of 1 to DNA, while human serum albumin was revealed as possible carrier for distribution of 1 in the blood stream.
Ključne reči:
Silver / Antiproliferative activity / Coordination polymers / Docking / Organic thiocyanatesIzvor:
Polyhedron, 2019, 173Izdavač:
- Elsevier
Finansiranje / projekti:
- Usmerena sinteza, struktura i svojstva multifunkcionalnih materijala (RS-MESTD-Basic Research (BR or ON)-172057)
DOI: 10.1016/j.poly.2019.114132
ISSN: 0277-5387
WoS: 000499768700039
Scopus: 2-s2.0-85072584514
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Filipović, Nenad R. AU - Ristić, Predrag AU - Janjić, Goran V. AU - Klisurić, Olivera AU - Puerta, A. AU - Padrón, José M. AU - Donnard, Morgan AU - Gulea, Mihaela AU - Todorović, Tamara PY - 2019 UR - https://cherry.chem.bg.ac.rs/handle/123456789/3509 AB - The first complexes of 2-pyridylthiocyanate (L) and silver nitrate (1) and perchlorate (2) were prepared and characterized by a single crystal X-ray analysis. The common structural motif of both 1 and 2 is coordination of two L molecules via pyridine nitrogen atom to Ag(I). In order to properly describe the nature of coordinative bonds in 1 and 2, as well as crystal packings in respective structures, a Quantum Theory of Atoms in Molecule topological analysis was performed. Coordinated nitrate ion provides more electron density to Ag(I) in comparison to perchlorate ion. Additional electron density in the case of 2 was provided by the coordination of third L molecule via thiocyanate nitrogen atom resulting in a 1D polymeric structure. Detailed computational analysis of intermolecular interactions, as well analysis of interactions between pyridine ring and –SCN group was performed. Antiproliferative activity of monomeric compound 1 was found to be better than of cisplatin on three out of four studied human cancer cell lines. Docking studies indicate intercalation as a major binding mode of 1 to DNA, while human serum albumin was revealed as possible carrier for distribution of 1 in the blood stream. PB - Elsevier T2 - Polyhedron T1 - Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study VL - 173 DO - 10.1016/j.poly.2019.114132 ER -
@article{ author = "Filipović, Nenad R. and Ristić, Predrag and Janjić, Goran V. and Klisurić, Olivera and Puerta, A. and Padrón, José M. and Donnard, Morgan and Gulea, Mihaela and Todorović, Tamara", year = "2019", abstract = "The first complexes of 2-pyridylthiocyanate (L) and silver nitrate (1) and perchlorate (2) were prepared and characterized by a single crystal X-ray analysis. The common structural motif of both 1 and 2 is coordination of two L molecules via pyridine nitrogen atom to Ag(I). In order to properly describe the nature of coordinative bonds in 1 and 2, as well as crystal packings in respective structures, a Quantum Theory of Atoms in Molecule topological analysis was performed. Coordinated nitrate ion provides more electron density to Ag(I) in comparison to perchlorate ion. Additional electron density in the case of 2 was provided by the coordination of third L molecule via thiocyanate nitrogen atom resulting in a 1D polymeric structure. Detailed computational analysis of intermolecular interactions, as well analysis of interactions between pyridine ring and –SCN group was performed. Antiproliferative activity of monomeric compound 1 was found to be better than of cisplatin on three out of four studied human cancer cell lines. Docking studies indicate intercalation as a major binding mode of 1 to DNA, while human serum albumin was revealed as possible carrier for distribution of 1 in the blood stream.", publisher = "Elsevier", journal = "Polyhedron", title = "Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study", volume = "173", doi = "10.1016/j.poly.2019.114132" }
Filipović, N. R., Ristić, P., Janjić, G. V., Klisurić, O., Puerta, A., Padrón, J. M., Donnard, M., Gulea, M.,& Todorović, T.. (2019). Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study. in Polyhedron Elsevier., 173. https://doi.org/10.1016/j.poly.2019.114132
Filipović NR, Ristić P, Janjić GV, Klisurić O, Puerta A, Padrón JM, Donnard M, Gulea M, Todorović T. Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study. in Polyhedron. 2019;173. doi:10.1016/j.poly.2019.114132 .
Filipović, Nenad R., Ristić, Predrag, Janjić, Goran V., Klisurić, Olivera, Puerta, A., Padrón, José M., Donnard, Morgan, Gulea, Mihaela, Todorović, Tamara, "Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study" in Polyhedron, 173 (2019), https://doi.org/10.1016/j.poly.2019.114132 . .