Highly oxygenated guaianolides from Anthemis carpatica
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The genus Anthemis L. (family Asteraceae, tribe Anthemidae) comprises about 130 species that commonly occur in the Mediterranean, although some also can be found in southwest Asia and South Africa.(1) In Serbia nine species are known.(2) Three main classes of compounds of chemosystematic interest, such as polyacetylenes, flavonoids, and sesquiterpene lactones, typical for Anthemidae, have been detected in the genus Anthemis.(3,4) Among the sesquiterpene lactones, only three types, that is, germacranolides (and seco-germacranolides),(5-15) eudesmanolides,(16,17) and guaianolides,(5,14,18,19) 19 have been isolated from the genus. The exception is an allergenic lactone with unusual structure (anthecotuloide), the constituent of A. cotula.(20,21) Continuing our chemotaxonomic examinations of the Yugoslavian flora belonging to Asteraceae and our search for new compounds of pharmacological interest, we now report the investigation of the aerial parts of Anthemis carpatica Willd, a species us...ually occurring at elevated, shady and grassy, sandy terrains of the Balkan Peninsula, eastern Alps, and east Carpathian Mountains.(2) A flavonoid quercetin(22) (leaves) and polyacetylenes(4) (roots) are the only secondary metabolites reported for A. carpatica.
Source:Journal of Natural Products, 1997, 60, 12, 1222-1228
- Amer Chemical Soc, Washington