Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization
Само за регистроване кориснике
2019
Аутори
Gandra, Upendar ReddySinopoli, Alessandro
Moncho, Salvador
Nanda Kumar, Manjula
Ninković, Dragan
Zarić, Snežana D.
Sohail, Muhammad
Al-Meer, Saeed
Brothers, Edward N.
Mazloum, Nayef A.
Al-Hashimi, Mohammed
Bazzi, Hassan S.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Carbon monoxide (CO) is an important biological gasotransmitter in living cells. Precise spatial and temporal control over release of CO is a major requirement for clinical application. To date, the most reported carbon monoxide releasing materials use expensive fabrication methods and require harmful and poorly designed tissue-penetrating UV irradiation to initiate the CO release precisely at infected sites. Herein, we report the first example of utilizing a green light-responsive CO-releasing polymer P synthesized via ring-opening metathesis polymerization. Both monomer M and polymer P were very stable under dark conditions and CO release was effectively triggered using minimal power and low energy wavelength irradiation (550 nm, ≤28 mW). Time-dependent density functional theory (TD-DFT) calculations were carried out to simulate the electronic transition and insight into the nature of the excitations for both L and M. TD-DFT calculations indicate that the absorption peak of M is main...ly due to the excitation of the seventh singlet excited state, S7. Furthermore, stretchable materials using polytetrafluoroethylene (PTFE) strips based on P were fabricated to afford P-PTFE, which can be used as a simple, inexpensive, and portable CO storage bandage. Insignificant cytotoxicity as well as cell permeability was found for M and P against human embryonic kidney cells.
Кључне речи:
carbon monoxide (CO) / CO-releasing material (CORMat) / light-responsive / polymer conjugates / portable CO storage and CO release bandageИзвор:
ACS Applied Materials and Interfaces, 2019, 11, 37, 34376-34384Издавач:
- American Chemical Society
DOI: 10.1021/acsami.9b12628
ISSN: 1944-8244
WoS: 000487179900091
Scopus: 2-s2.0-85072508757
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Gandra, Upendar Reddy AU - Sinopoli, Alessandro AU - Moncho, Salvador AU - Nanda Kumar, Manjula AU - Ninković, Dragan AU - Zarić, Snežana D. AU - Sohail, Muhammad AU - Al-Meer, Saeed AU - Brothers, Edward N. AU - Mazloum, Nayef A. AU - Al-Hashimi, Mohammed AU - Bazzi, Hassan S. PY - 2019 UR - https://cherry.chem.bg.ac.rs/handle/123456789/3636 AB - Carbon monoxide (CO) is an important biological gasotransmitter in living cells. Precise spatial and temporal control over release of CO is a major requirement for clinical application. To date, the most reported carbon monoxide releasing materials use expensive fabrication methods and require harmful and poorly designed tissue-penetrating UV irradiation to initiate the CO release precisely at infected sites. Herein, we report the first example of utilizing a green light-responsive CO-releasing polymer P synthesized via ring-opening metathesis polymerization. Both monomer M and polymer P were very stable under dark conditions and CO release was effectively triggered using minimal power and low energy wavelength irradiation (550 nm, ≤28 mW). Time-dependent density functional theory (TD-DFT) calculations were carried out to simulate the electronic transition and insight into the nature of the excitations for both L and M. TD-DFT calculations indicate that the absorption peak of M is mainly due to the excitation of the seventh singlet excited state, S7. Furthermore, stretchable materials using polytetrafluoroethylene (PTFE) strips based on P were fabricated to afford P-PTFE, which can be used as a simple, inexpensive, and portable CO storage bandage. Insignificant cytotoxicity as well as cell permeability was found for M and P against human embryonic kidney cells. PB - American Chemical Society T2 - ACS Applied Materials and Interfaces T1 - Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization VL - 11 IS - 37 SP - 34376 EP - 34384 DO - 10.1021/acsami.9b12628 ER -
@article{ author = "Gandra, Upendar Reddy and Sinopoli, Alessandro and Moncho, Salvador and Nanda Kumar, Manjula and Ninković, Dragan and Zarić, Snežana D. and Sohail, Muhammad and Al-Meer, Saeed and Brothers, Edward N. and Mazloum, Nayef A. and Al-Hashimi, Mohammed and Bazzi, Hassan S.", year = "2019", abstract = "Carbon monoxide (CO) is an important biological gasotransmitter in living cells. Precise spatial and temporal control over release of CO is a major requirement for clinical application. To date, the most reported carbon monoxide releasing materials use expensive fabrication methods and require harmful and poorly designed tissue-penetrating UV irradiation to initiate the CO release precisely at infected sites. Herein, we report the first example of utilizing a green light-responsive CO-releasing polymer P synthesized via ring-opening metathesis polymerization. Both monomer M and polymer P were very stable under dark conditions and CO release was effectively triggered using minimal power and low energy wavelength irradiation (550 nm, ≤28 mW). Time-dependent density functional theory (TD-DFT) calculations were carried out to simulate the electronic transition and insight into the nature of the excitations for both L and M. TD-DFT calculations indicate that the absorption peak of M is mainly due to the excitation of the seventh singlet excited state, S7. Furthermore, stretchable materials using polytetrafluoroethylene (PTFE) strips based on P were fabricated to afford P-PTFE, which can be used as a simple, inexpensive, and portable CO storage bandage. Insignificant cytotoxicity as well as cell permeability was found for M and P against human embryonic kidney cells.", publisher = "American Chemical Society", journal = "ACS Applied Materials and Interfaces", title = "Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization", volume = "11", number = "37", pages = "34376-34384", doi = "10.1021/acsami.9b12628" }
Gandra, U. R., Sinopoli, A., Moncho, S., Nanda Kumar, M., Ninković, D., Zarić, S. D., Sohail, M., Al-Meer, S., Brothers, E. N., Mazloum, N. A., Al-Hashimi, M.,& Bazzi, H. S.. (2019). Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization. in ACS Applied Materials and Interfaces American Chemical Society., 11(37), 34376-34384. https://doi.org/10.1021/acsami.9b12628
Gandra UR, Sinopoli A, Moncho S, Nanda Kumar M, Ninković D, Zarić SD, Sohail M, Al-Meer S, Brothers EN, Mazloum NA, Al-Hashimi M, Bazzi HS. Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization. in ACS Applied Materials and Interfaces. 2019;11(37):34376-34384. doi:10.1021/acsami.9b12628 .
Gandra, Upendar Reddy, Sinopoli, Alessandro, Moncho, Salvador, Nanda Kumar, Manjula, Ninković, Dragan, Zarić, Snežana D., Sohail, Muhammad, Al-Meer, Saeed, Brothers, Edward N., Mazloum, Nayef A., Al-Hashimi, Mohammed, Bazzi, Hassan S., "Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization" in ACS Applied Materials and Interfaces, 11, no. 37 (2019):34376-34384, https://doi.org/10.1021/acsami.9b12628 . .