Synthesis of two novel C-19 analogues of (±)-alstoscholarisine A
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Two new analogues of alstoscholarisine A, containing a phenyl or butyl substituent at the C-19 position, have been prepared in racemic form from the known skatole derivative. The syntheses of these compounds were accomplished in 13 steps, with a late-stage formation of the C-19 stereocenter. These derivatives are expected to have significantly changed biological activity, compared to alstoscholarisine A – a potent neuroactive natural product.
Keywords:Alstonia scholaris / Neuronal stem cells / аlkaloids
Source:Journal of the Serbian Chemical Society, 2019, 84, 9, 935-941
- Beograd : Srpsko hemijsko društvo