Thin-layer chromatography in medicinal chemistry
Authorized Users Only
Article (Published version)
MetadataShow full item record
Among widely used chromatographic methods modern thin-layer chromatography is not only the simplest to perform but is also considered as respectable analytical method in various phases of drug discovery and development processes such as monitoring of synthesis, identification of bioactive substances from various natural sources and their isolation and purification, determination of lipophilicity and other physico-chemical parameters, quantitative structure-activity relationship studies, bioautography, as well as qualitative and quantitative analysis of drugs and their metabolites. An overview of recently published papers dealing with application of thin-layer chromatography in medicinal chemistry is presented.
Keywords:ADMET parameters / bioautography / lipophilicity / TLC in drug development
Source:Journal of Liquid Chromatography and Related Technologies, 2019, 42, 9-10, 238-248
- Taylor and Francis Inc.