Investigation of lipophilicity and pharmacokinetic properties of 2-(methoxy)phenylpiperazine dopamine D2 ligands
Authorized Users Only
2019
Authors
Šegan, Sandra B.Penjišević, Jelena
Šukalović, Vladimir
Andrić, Deana
Milojković-Opsenica, Dušanka
Kostić-Rajačić, Slađana
Metadata
Show full item recordAbstract
Reversed-phase thin-layer chromatography and micellar thin-layer chromatography were used in order to investigate retention behaviour and to determine lipophilicity of series of 2-(methoxy)phenylpiperazine dopamine D2 ligands with different size, shape and rigidity. The retention mechanism was discussed. The lipophilicity parameters obtained in conventional reversed-phase systems expressed as RM 0 and C0, as well as RM values determined in microemulsion reversed-phase systems were correlated with in silico determined lipophilicity values. In silico pharmacokinetic properties of 2-(methoxy)phenylpiperazine dopamine D2 ligands revealed the importance of experimentally determined lipophilicity values besides the molecular weight, on the blood–brain barrier permeability process. Also, the experimentally determined lipophilicity was found as a very important factor in plasma protein binding process of 2-(methoxy)phenylpiperazine dopamine D2 ligands. Besides, the Lipinski's rule of five indi...cates that examined ligands satisfy the criterion of drug-like molecules. The principal component analysis was performed on the experimentally determined and calculated lipophilicity values as well on the molecular descriptors which describe the pharmacokinetic properties in order to provide basic insights into similarities among the studied ligands.
Keywords:
2-(Methoxy)phenylpiperazine dopamine D2 ligands / Blood–brain barrier (BBB) permeability / Lipophilicity / Microemulsion thin-layer chromatography (METLC) / Protein binding capacity (QPlogKhsa) / Reversed-phase thin-layer chromatography (RPTLC)Source:
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2019, 1124, 146-153Publisher:
- Elsevier
Funding / projects:
- The synthesis of aminoquinoline-based antimalarials and botulinum neurotoxin A inhibitors (RS-MESTD-Basic Research (BR or ON)-172008)
- Structure-activity relationship of newly synthesized biological active compound (RS-MESTD-Basic Research (BR or ON)-172032)
Note:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3697
DOI: 10.1016/j.jchromb.2019.06.006
ISSN: 1570-0232
WoS: 000477685600015
Scopus: 2-s2.0-85067083868
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Institution/Community
Hemijski fakultet / Faculty of ChemistryŠegan, S. B., Penjišević, J., Šukalović, V., Andrić, D., Milojković-Opsenica, D.,& Kostić-Rajačić, S.. (2019). Investigation of lipophilicity and pharmacokinetic properties of 2-(methoxy)phenylpiperazine dopamine D2 ligands. in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences Elsevier., 1124, 146-153. https://doi.org/10.1016/j.jchromb.2019.06.006
Šegan SB, Penjišević J, Šukalović V, Andrić D, Milojković-Opsenica D, Kostić-Rajačić S. Investigation of lipophilicity and pharmacokinetic properties of 2-(methoxy)phenylpiperazine dopamine D2 ligands. in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 2019;1124:146-153. doi:10.1016/j.jchromb.2019.06.006 .
Šegan, Sandra B., Penjišević, Jelena, Šukalović, Vladimir, Andrić, Deana, Milojković-Opsenica, Dušanka, Kostić-Rajačić, Slađana, "Investigation of lipophilicity and pharmacokinetic properties of 2-(methoxy)phenylpiperazine dopamine D2 ligands" in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1124 (2019):146-153, https://doi.org/10.1016/j.jchromb.2019.06.006 . .