Disposable Biosensor Based on Amidase/CeO2/GNR Modified Inkjet-printed CNT Electrodes-droplet Based Paracetamol Detection in Biological Fluids for “Point-of-care” Applications
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Girault, Hubert H.
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A disposable acetaminophen biosensor based on inkjet-printed CNT electrodes (IJPCNT) modified with amidase/cerium dioxide@graphene nanoribbons composite was developed (ACeO2@GNR/IJPCNT). The enzyme amidase A was used for the first time as a recognition element. Inkjet-printed CNT electrodes served as a basis for the construction of a biosensor that enables droplet detection using 5 μL sample volume. The biosensor showed high selectivity, sensitivity, a low detection limit of 0.18 μM and a wide working linear range from 1 to 100 μM. The proposed approach allows fast and reliable detection of acetaminophen in biological fluids with negligible matrix effect and remarkable reproducibility.
Keywords:acetaminophen / amidase / biosensor / cerium dioxide/graphene nanoribbons composite / inkjet-printed sensors
Source:Electroanalysis, 2019, 31, 8, 1534-1542
- Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
- Magbiovin project (FP7- ERAChairs-Pilot Call-2013, Grant agreement: 621375)
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