A real-life study of the efficacy of sublingual immunotherapy against weed allergies in the Serbian population
Étude en vraie vie de l'efficacité de la désensibilisation par voie sublinguale pour les pollens d'herbacées dans la population serbe
Само за регистроване кориснике
2019
Аутори
Tadić, D.Popović, Milica M.
Gavrović-Jankulović, Marija
Đurić, Vojislav
Tomić-Špirić, Vesna
Rašković, Sanvila S.
Perić Popadić, Aleksandra
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Introduction: In the Serbian population allergy to weed pollen is the most common type of pollen-associated allergy, ahead of grass and tree pollens. Besides causing discomfort, allergy to pollen is often associated with rhinitis and asthma. Allergen-specific immunotherapy (ASIT) is the only treatment that can lead to potential long-term immune modification while reducing development of new sensitization and halting disease progression. The aim of the present study is to evaluate the efficacy of sublingual immunotherapy (SLIT) to weeds in the adult patient population using vaccine produced by the local Serbian Torlak Institute for virology, vaccines and serum. Methods: Adult patients with a clinical history of allergic rhinitis with and without asthma were included in the study. IgE-mediated sensitization to grass, tree and weed pollens was confirmed by skin prick testing and/or positive specific IgE. Patients were divided into two groups: patients with allergy to tree and grass pollen... and patients with allergy to weeds. All patients received SLIT for three years, either with or without additional symptomatic therapy. Results: Three-year SLIT therapy led to significant improvement in several parameters, including skin-prick reactivity, decrease in specific IgE and use of symptomatic therapy, with mild adverse effects and high patient satisfaction concerning therapy. Conclusion: Three-year SLIT is a safe and efficient treatment option for respiratory allergy to weeds. Further observations in a larger number of patients could provide a better epidemiological evaluation of SLIT, but the positive effects we observed in our study may be considered representative despite the small number of patients.
Кључне речи:
Allergic rhinitis / Asthma / Sublingual immunotherapy / Weed allergyИзвор:
Revue Francaise d'Allergologie, 2019, 59, 7, 474-480Издавач:
- Elsevier
Финансирање / пројекти:
- Алергени, антитела, ензими и мали физиолошки значајни молекули: дизајн, структура, функција и значај (RS-MESTD-Basic Research (BR or ON)-172049)
- Развој нових информационо-комуникационих технологија, коришћењем напредних математичких метода, са применама у медицини, телекомуникацијама, енергетици, заштитити националне баштине и образовању (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-44006)
DOI: 10.1016/j.reval.2019.05.006
ISSN: 1877-0320
WoS: 000502685800004
Scopus: 2-s2.0-85070547824
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Tadić, D. AU - Popović, Milica M. AU - Gavrović-Jankulović, Marija AU - Đurić, Vojislav AU - Tomić-Špirić, Vesna AU - Rašković, Sanvila S. AU - Perić Popadić, Aleksandra PY - 2019 UR - https://cherry.chem.bg.ac.rs/handle/123456789/3728 AB - Introduction: In the Serbian population allergy to weed pollen is the most common type of pollen-associated allergy, ahead of grass and tree pollens. Besides causing discomfort, allergy to pollen is often associated with rhinitis and asthma. Allergen-specific immunotherapy (ASIT) is the only treatment that can lead to potential long-term immune modification while reducing development of new sensitization and halting disease progression. The aim of the present study is to evaluate the efficacy of sublingual immunotherapy (SLIT) to weeds in the adult patient population using vaccine produced by the local Serbian Torlak Institute for virology, vaccines and serum. Methods: Adult patients with a clinical history of allergic rhinitis with and without asthma were included in the study. IgE-mediated sensitization to grass, tree and weed pollens was confirmed by skin prick testing and/or positive specific IgE. Patients were divided into two groups: patients with allergy to tree and grass pollen and patients with allergy to weeds. All patients received SLIT for three years, either with or without additional symptomatic therapy. Results: Three-year SLIT therapy led to significant improvement in several parameters, including skin-prick reactivity, decrease in specific IgE and use of symptomatic therapy, with mild adverse effects and high patient satisfaction concerning therapy. Conclusion: Three-year SLIT is a safe and efficient treatment option for respiratory allergy to weeds. Further observations in a larger number of patients could provide a better epidemiological evaluation of SLIT, but the positive effects we observed in our study may be considered representative despite the small number of patients. PB - Elsevier T2 - Revue Francaise d'Allergologie T1 - A real-life study of the efficacy of sublingual immunotherapy against weed allergies in the Serbian population VL - 59 IS - 7 SP - 474 EP - 480 DO - 10.1016/j.reval.2019.05.006 ER -
@article{ author = "Tadić, D. and Popović, Milica M. and Gavrović-Jankulović, Marija and Đurić, Vojislav and Tomić-Špirić, Vesna and Rašković, Sanvila S. and Perić Popadić, Aleksandra", year = "2019", abstract = "Introduction: In the Serbian population allergy to weed pollen is the most common type of pollen-associated allergy, ahead of grass and tree pollens. Besides causing discomfort, allergy to pollen is often associated with rhinitis and asthma. Allergen-specific immunotherapy (ASIT) is the only treatment that can lead to potential long-term immune modification while reducing development of new sensitization and halting disease progression. The aim of the present study is to evaluate the efficacy of sublingual immunotherapy (SLIT) to weeds in the adult patient population using vaccine produced by the local Serbian Torlak Institute for virology, vaccines and serum. Methods: Adult patients with a clinical history of allergic rhinitis with and without asthma were included in the study. IgE-mediated sensitization to grass, tree and weed pollens was confirmed by skin prick testing and/or positive specific IgE. Patients were divided into two groups: patients with allergy to tree and grass pollen and patients with allergy to weeds. All patients received SLIT for three years, either with or without additional symptomatic therapy. Results: Three-year SLIT therapy led to significant improvement in several parameters, including skin-prick reactivity, decrease in specific IgE and use of symptomatic therapy, with mild adverse effects and high patient satisfaction concerning therapy. Conclusion: Three-year SLIT is a safe and efficient treatment option for respiratory allergy to weeds. Further observations in a larger number of patients could provide a better epidemiological evaluation of SLIT, but the positive effects we observed in our study may be considered representative despite the small number of patients.", publisher = "Elsevier", journal = "Revue Francaise d'Allergologie", title = "A real-life study of the efficacy of sublingual immunotherapy against weed allergies in the Serbian population", volume = "59", number = "7", pages = "474-480", doi = "10.1016/j.reval.2019.05.006" }
Tadić, D., Popović, M. M., Gavrović-Jankulović, M., Đurić, V., Tomić-Špirić, V., Rašković, S. S.,& Perić Popadić, A.. (2019). A real-life study of the efficacy of sublingual immunotherapy against weed allergies in the Serbian population. in Revue Francaise d'Allergologie Elsevier., 59(7), 474-480. https://doi.org/10.1016/j.reval.2019.05.006
Tadić D, Popović MM, Gavrović-Jankulović M, Đurić V, Tomić-Špirić V, Rašković SS, Perić Popadić A. A real-life study of the efficacy of sublingual immunotherapy against weed allergies in the Serbian population. in Revue Francaise d'Allergologie. 2019;59(7):474-480. doi:10.1016/j.reval.2019.05.006 .
Tadić, D., Popović, Milica M., Gavrović-Jankulović, Marija, Đurić, Vojislav, Tomić-Špirić, Vesna, Rašković, Sanvila S., Perić Popadić, Aleksandra, "A real-life study of the efficacy of sublingual immunotherapy against weed allergies in the Serbian population" in Revue Francaise d'Allergologie, 59, no. 7 (2019):474-480, https://doi.org/10.1016/j.reval.2019.05.006 . .