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dc.creatorDinić, Jelena
dc.creatorPodolski-Renić, Ana
dc.creatorJeremić, Marko
dc.creatorPešić, Milica
dc.date.accessioned2019-12-11T16:30:04Z
dc.date.available2019-12-11T16:30:04Z
dc.date.issued2018
dc.identifier.issn1381-6128
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/3750
dc.description.abstractMedicinal value of natural products comes from symbiotic and competitive evolution in Earth’s complex biosphere. Billions of years of co-evolutionary interactions among millions of species have produced a large repertoire of defense molecules effective in fighting bacteria, viral, and fungal pathogens. Each species contains millions of different and useful molecules and new research technologies enabled the screening of molecules and complex mixtures from diverse biological sources. Traditional use of plants and other species led to the discovery of many bioactive compounds with various properties. In the last four decades, a large number of them were evaluated for their potential to treat cancer. Penetration of drugs into the cancer cell is necessary for their lethal pharmacological effect through interaction with intracellular target molecules. Increased activity of membrane efflux pumps reduces the intracellular drug accumulation, thereby preventing drug-target interactions. The discovery of the efflux transporter P-glycoprotein (P-gp) in multidrug resistant (MDR) cancer cells prompted the efforts in overcoming drug resistance by P-gp inhibition. The search for nontoxic anticancer agents from natural sources able to overcome MDR has been imperative in the field of drug design and discovery. Herein, we review various natural compounds from diverse sources emphasizing their potential to inhibit P-gp activity and/or expression.
dc.publisherBentham Science Publishers B.V.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41031/RS//
dc.relationCOST Actions CM1106 (Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells)
dc.relationCM1407 (Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery)
dc.rightsrestrictedAccess
dc.sourceCurrent Pharmaceutical Design
dc.subjectAnticancer compounds
dc.subjectATP-Binding Cassette transporters
dc.subjectMultidrug resistance
dc.subjectNatural products
dc.subjectP-glycoprotein
dc.subjectTraditional medicine
dc.titlePotential of natural-based anticancer compounds for P-glycoprotein inhibition
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДинић, Јелена; Пешић, Милица; Јеремић, Марко; Подолски-Ренић, Aна;
dc.citation.volume24
dc.citation.issue36
dc.citation.spage4334
dc.citation.epage4354
dc.identifier.wos000458726500007
dc.identifier.doi10.2174/1381612825666190112164211
dc.citation.rankM22
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85063669655


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