Naphthoquinones of natural origin: Aqueous chemistry and coordination to half-sandwich organometallic cations
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AuthorsMészáros, János P.
Legina, Maria S.
Jakupec, Michael A.
Keppler, Bernhard K.
Enyedy, Éva A.
Article (Published version)
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Half-sandwich organometallic complexes featuring Ru(II), Os(II) and Rh(III) metal centers and naturally occurring bidentate 2-hydroxy-[1,4]-naphthoquinone ligands (lawsone and phthiocol) have been synthesized and characterized in both solid state and solution phase by analytical, spectroscopic, electrochemical and single crystal X-ray diffraction techniques. Comparative studies revealed the influence of the respective metal center (Ru, Os, Rh), leaving group (Cl, Br, I) and arene (p-cymene, toluene, pentamethylcyclopentadienyl), as well as the naphthoquinone ligand on the structural properties and solution speciation. Additionally, cytotoxicity was tested in SW480, CH1/PA-1 and A549 human cancer cell lines showing a broad range of IC50 values.
Keywords:Cytotoxicity / Half-sandwich complexes / Natural ligands / Solution stability / X-ray crystal structures
Source:Journal of Organometallic Chemistry, 2020, 907
- GINOP-2.3.2-15- 2016-00038
- FK 124240
- FIKP program TUDFO/47138e1/2019- ITM. J.P. M
- ÚNKP-19-3 National Excellence Program of the Ministry for Innovation and Technology
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3805