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Optimization of extraction yield and chemical characterization of optimal extract from Juglans nigra L. leaves
dc.creator | Rajković, Katarina M. | |
dc.creator | Vasić, Marijana | |
dc.creator | Drobac, Milica | |
dc.creator | Mutić, Jelena | |
dc.creator | Jeremić, Sanja | |
dc.creator | Simić, Valentina | |
dc.creator | Stanković, Jovana | |
dc.date.accessioned | 2020-03-31T19:57:39Z | |
dc.date.available | 2022-03-02 | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0263-8762 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/3897 | |
dc.description.abstract | The extraction yield of Juglans nigra L. leaves was assessed at different ethanol concentrations (0–96% (v/v)) and solvent-to-solid ratios (5–20 kg kg−1). The response surface methodology (RSM) and artificial neural network with genetic algorithms (ANN-GA) were developed to optimize the extraction variables. The RSM and ANN-GA models determined 50% (v/v) ethanol concentration and 20 kg kg−1 solvent-to-solid ratio as optimal conditions, ensuring an extraction yield of 27.69 and 27.19 g 100 g−1 of dry leaves. The phenolic compounds in optimal extract were quantified: 3-O-caffeoylquinic acid (2.27 mg g−1of dry leaves), quercetin-3-O-galactoside (10.99 mg g−1 of dry leaves) and quercetin-3-O-rhamnoside (15.07 mg g−1of dry leaves) using high-performance liquid chromatography (HPLC). The minerals in optimal extract were quantified: macro-elements (the relative order by content was: K > Mg > Ca) using inductively coupled plasma optical emission spectrometry (ICP-OES) and micro-elements (the relative order by content was: Zn > Rb > Mn > I>Sr > Ni > Cu > Co > V > Ag > Se) using inductively coupled plasma mass spectrometry (ICP-MS). The extraction coefficients for minerals were determined and were highest for K (64.3%) and I (53.5%). Optimization of extraction process resulted in high extraction yield from J. nigra leaves and optimal extract containing different phytochemical compounds. | |
dc.publisher | Elsevier | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175034/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173020/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS// | |
dc.rights | embargoedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Chemical Engineering Research and Design | |
dc.subject | Artificial neural network | |
dc.subject | Juglans nigra | |
dc.subject | Minerals | |
dc.subject | Phenolic constituents | |
dc.subject | Response surface methodology | |
dc.title | Optimization of extraction yield and chemical characterization of optimal extract from Juglans nigra L. leaves | |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Дробац, Милица; Мутић, Јелена; Јеремић, Сања; Симић, Валентина; Рајковић, Катарина М.; Станковић, Јован; Васић, Маријана; | |
dc.citation.volume | 157 | |
dc.citation.spage | 25 | |
dc.citation.epage | 33 | |
dc.identifier.wos | 000528193200003 | |
dc.identifier.doi | 10.1016/j.cherd.2020.03.002 | |
dc.citation.rank | M22~ | |
dc.description.other | This is the peer-reviewed version of the article: Rajković, K. M.; Vasić, M.; Drobac, M.; Mutić, J.; Jeremić, S.; Simić, V.; Stanković, J. Optimization of Extraction Yield and Chemical Characterization of Optimal Extract from Juglans Nigra L. Leaves. Chemical Engineering Research and Design 2020, 157, 25–33. [https://doi.org/10.1016/j.cherd.2020.03.002] | |
dc.type.version | acceptedVersion | |
dc.identifier.scopus | 2-s2.0-85081647717 | |
dc.identifier.fulltext | http://cherry.chem.bg.ac.rs/bitstream/id/16861/Optimization_of_extraction_acc_2020.pdf |