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Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease
The background level of lead (Pb) in drinking water in Serbia represents a significant health issue. The aim of study was to examine the content of significant toxic and essential trace metals (Mn, Ni, Cu, Zn, As, Se, Cd, Pb, Th, and U) in the thyroid tissues with diagnosed colloid goiter (CG). Different variables were investigated (sex, age, smoking habits, goiter size, and previous history of any thyroid disease). The study was designed to compare the goiter tissues (GTs) to sex- and age-matched healthy- and malignant-thyroid tissues (HTTs and MTTs, respectively). All trace metals were quantified by inductively coupled plasma mass spectrometry (ICP-MS). The reduced content of essential elements (Mn and Se) and increased content of toxic metals (Pb, Th, and U) were found in GTs compared with HTTs. The increased content of the same toxic metals separated GTs from MTTs, as well as reduced content of Mn and Cd. Our results indicated that Pb acts as the main goitrogen, which could highlig...ht its role in the unknown etiology of CG disease. Pb/Se ratio could be considered as a relevant parameter for the tissue separation of GTs from HTTs and/or MTTs. This research also provides novel data on the effects of metal pollutants on thyroid health hazards. Graphical Abstract: [Figure not available: see fulltext.].
Keywords:
Colloid goiter / Lead (Pb) / Pb/Se ratio / Thyroid tissues / Trace metals
TY - JOUR
AU - Stojsavljević, Aleksandar
AU - Rovčanin, Branislav
AU - Krstić, Đurđa D.
AU - Borković-Mitić, Slavica S.
AU - Paunović, Ivan
AU - Diklić, Aleksandar
AU - Gavrović-Jankulović, Marija
AU - Manojlović, Dragan D.
PY - 2020
UR - https://cherry.chem.bg.ac.rs/handle/123456789/3955
AB - The background level of lead (Pb) in drinking water in Serbia represents a significant health issue. The aim of study was to examine the content of significant toxic and essential trace metals (Mn, Ni, Cu, Zn, As, Se, Cd, Pb, Th, and U) in the thyroid tissues with diagnosed colloid goiter (CG). Different variables were investigated (sex, age, smoking habits, goiter size, and previous history of any thyroid disease). The study was designed to compare the goiter tissues (GTs) to sex- and age-matched healthy- and malignant-thyroid tissues (HTTs and MTTs, respectively). All trace metals were quantified by inductively coupled plasma mass spectrometry (ICP-MS). The reduced content of essential elements (Mn and Se) and increased content of toxic metals (Pb, Th, and U) were found in GTs compared with HTTs. The increased content of the same toxic metals separated GTs from MTTs, as well as reduced content of Mn and Cd. Our results indicated that Pb acts as the main goitrogen, which could highlight its role in the unknown etiology of CG disease. Pb/Se ratio could be considered as a relevant parameter for the tissue separation of GTs from HTTs and/or MTTs. This research also provides novel data on the effects of metal pollutants on thyroid health hazards. Graphical Abstract: [Figure not available: see fulltext.].
T2 - Exposure and Health
T1 - Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease
VL - 12
IS - 2
SP - 255
EP - 264
DO - 10.1007/s12403-019-00309-9
ER -
@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Branislav and Krstić, Đurđa D. and Borković-Mitić, Slavica S. and Paunović, Ivan and Diklić, Aleksandar and Gavrović-Jankulović, Marija and Manojlović, Dragan D.",
year = "2020",
abstract = "The background level of lead (Pb) in drinking water in Serbia represents a significant health issue. The aim of study was to examine the content of significant toxic and essential trace metals (Mn, Ni, Cu, Zn, As, Se, Cd, Pb, Th, and U) in the thyroid tissues with diagnosed colloid goiter (CG). Different variables were investigated (sex, age, smoking habits, goiter size, and previous history of any thyroid disease). The study was designed to compare the goiter tissues (GTs) to sex- and age-matched healthy- and malignant-thyroid tissues (HTTs and MTTs, respectively). All trace metals were quantified by inductively coupled plasma mass spectrometry (ICP-MS). The reduced content of essential elements (Mn and Se) and increased content of toxic metals (Pb, Th, and U) were found in GTs compared with HTTs. The increased content of the same toxic metals separated GTs from MTTs, as well as reduced content of Mn and Cd. Our results indicated that Pb acts as the main goitrogen, which could highlight its role in the unknown etiology of CG disease. Pb/Se ratio could be considered as a relevant parameter for the tissue separation of GTs from HTTs and/or MTTs. This research also provides novel data on the effects of metal pollutants on thyroid health hazards. Graphical Abstract: [Figure not available: see fulltext.].",
journal = "Exposure and Health",
title = "Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease",
volume = "12",
number = "2",
pages = "255-264",
doi = "10.1007/s12403-019-00309-9"
}
Stojsavljević, A., Rovčanin, B., Krstić, Đ. D., Borković-Mitić, S. S., Paunović, I., Diklić, A., Gavrović-Jankulović, M.,& Manojlović, D. D.. (2020). Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease. in Exposure and Health, 12(2), 255-264.
https://doi.org/10.1007/s12403-019-00309-9
Stojsavljević A, Rovčanin B, Krstić ĐD, Borković-Mitić SS, Paunović I, Diklić A, Gavrović-Jankulović M, Manojlović DD. Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease. in Exposure and Health. 2020;12(2):255-264.
doi:10.1007/s12403-019-00309-9 .
Stojsavljević, Aleksandar, Rovčanin, Branislav, Krstić, Đurđa D., Borković-Mitić, Slavica S., Paunović, Ivan, Diklić, Aleksandar, Gavrović-Jankulović, Marija, Manojlović, Dragan D., "Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease" in Exposure and Health, 12, no. 2 (2020):255-264,
https://doi.org/10.1007/s12403-019-00309-9 . .
