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Polyphenols as Possible Agents for Pancreatic Diseases

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2020
Polyphenols_as_Possible_pub_2020.pdf (979.5Kb)
Authors
Gašić, Uroš M.
Ćirić, Ivanka
Pejčić, Tomislav
Radenković, Dejan
Đorđević, Vladimir
Radulović, Siniša
Tešić, Živoslav Lj.
Article (Published version)
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Abstract
Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lin...es as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.

Keywords:
pancreatic diseases / polyphenol bioavailability / polyphenols / quercetin / resveratrol / synergistic effects
Source:
Antioxidants, 2020, 9, 6, 547-
Publisher:
  • MDPI
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200288 (Innovation Center of the Faculty of Chemistry) (RS-200288)
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200168 (University of Belgrade, Faculty of Chemistry) (RS-200168)
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-200007)

DOI: 10.3390/antiox9060547

ISSN: 2076-3921

WoS: 000551230800001

Scopus: 2-s2.0-85090686538
[ Google Scholar ]
8
6
URI
https://cherry.chem.bg.ac.rs/handle/123456789/4080
Collections
  • Publikacije
  • Publikacije
Institution/Community
Hemijski fakultet
TY  - JOUR
AU  - Gašić, Uroš M.
AU  - Ćirić, Ivanka
AU  - Pejčić, Tomislav
AU  - Radenković, Dejan
AU  - Đorđević, Vladimir
AU  - Radulović, Siniša
AU  - Tešić, Živoslav Lj.
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4080
AB  - Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.
PB  - MDPI
T2  - Antioxidants
T1  - Polyphenols as Possible Agents for Pancreatic Diseases
VL  - 9
IS  - 6
SP  - 547
DO  - 10.3390/antiox9060547
ER  - 
@article{
author = "Gašić, Uroš M. and Ćirić, Ivanka and Pejčić, Tomislav and Radenković, Dejan and Đorđević, Vladimir and Radulović, Siniša and Tešić, Živoslav Lj.",
year = "2020",
abstract = "Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.",
publisher = "MDPI",
journal = "Antioxidants",
title = "Polyphenols as Possible Agents for Pancreatic Diseases",
volume = "9",
number = "6",
pages = "547",
doi = "10.3390/antiox9060547"
}
Gašić, U. M., Ćirić, I., Pejčić, T., Radenković, D., Đorđević, V., Radulović, S.,& Tešić, Ž. Lj.. (2020). Polyphenols as Possible Agents for Pancreatic Diseases. in Antioxidants
MDPI., 9(6), 547.
https://doi.org/10.3390/antiox9060547
Gašić UM, Ćirić I, Pejčić T, Radenković D, Đorđević V, Radulović S, Tešić ŽL. Polyphenols as Possible Agents for Pancreatic Diseases. in Antioxidants. 2020;9(6):547.
doi:10.3390/antiox9060547 .
Gašić, Uroš M., Ćirić, Ivanka, Pejčić, Tomislav, Radenković, Dejan, Đorđević, Vladimir, Radulović, Siniša, Tešić, Živoslav Lj., "Polyphenols as Possible Agents for Pancreatic Diseases" in Antioxidants, 9, no. 6 (2020):547,
https://doi.org/10.3390/antiox9060547 . .

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