Guaianolides from Centaurea nicolai: antifungal activity
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Todorović, Nevena M.
Janaćković, Peđa T.
Marin, Petar D.
Article (Published version)
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A new guaianolide, 3-deacetyl-9-O-acetylsalograviolide A, along with four known closely related lactones, salograviolide A, 9-O-acetylsalograviolide A, kandavanolide and salograviolide B were detected in the aerial parts of the flowering plant Centaurea nicolai. Antifungal tests performed on salograviolide A and its 9-O-acetyl and 3-O-deacetyl-9-O-acetyl derivatives revealed inhibitory activity against Aspergillus niger, A. ochraceus, Penticillium ochrochloron,Cladosporium cladosporodies, Fusharium tricinctum and Phomopsis helianthi. Neither of them was active against Trichoderma viride. (C) 1999 Elsevier Science Ltd. All rights reserved.
Keywords:Centaurea nicolai / asteraceae / aerial parts / sesquiterpene lactones / guaianolides / antifungal activity
Source:Phytochemistry, 1999, 52, 3, 383-386
- Pergamon-Elsevier Science Ltd, Oxford