Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives
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2021
Authors
Đukanović, NinaObradović, Slobodan
Zdravković, Marija
Đurašević, Siniša
Stojković, Maja
Jasnić, Nebojša
Popović-Đorđević, Jelena
Todorović, Zoran B.
Tosti, Tomislav
Article (Published version)
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Show full item recordAbstract
Lipids play an essential role in platelet functions. It is known that polyunsaturated fatty acids play a role in increasing platelet reactivity and that the prothrombotic phenotype plays a crucial role in the occurrence of major adverse cardiovascular events. The ongoing increase in cardiovascular diseases’ incidence emphasizes the importance of research linking lipids and platelet function. In particular, the rebound phenomenon that accompanies discontinuation of clopidogrel in patients receiving dual antiplatelet therapy has been associated with changes in the lipid profile. Our many years of research underline the importance of reduced HDL values for the risk of such a rebound effect and the occurrence of thromboembolic events. Lipids are otherwise a heterogeneous group of molecules, and their signaling molecules are not deposited but formed “on-demand” in the cell. On the other hand, exosomes transmit lipid signals between cells, and the profile of such changes can be monitored by ...lipidomics. Changes in the lipid profile are organ-specific and may indicate new drug action targets.
Keywords:
discontinuation / HDL / P2Y12 inhibitorsSource:
International Journal of Molecular Sciences, 2021, 22, 6, 3180-Publisher:
- MDPI
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200110 (University of Belgrade, Faculty of Medicine) (RS-MESTD-inst-2020-200110)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200178 (University of Belgrade, Faculty of Biology) (RS-MESTD-inst-2020-200178)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200168 (University of Belgrade, Faculty of Chemistry) (RS-MESTD-inst-2020-200168)
DOI: 10.3390/ijms22063180
ISSN: 1422-0067
WoS: 000645722000001
Scopus: 2-s2.0-85102730560
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Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Đukanović, Nina AU - Obradović, Slobodan AU - Zdravković, Marija AU - Đurašević, Siniša AU - Stojković, Maja AU - Jasnić, Nebojša AU - Popović-Đorđević, Jelena AU - Todorović, Zoran B. AU - Tosti, Tomislav PY - 2021 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4361 AB - Lipids play an essential role in platelet functions. It is known that polyunsaturated fatty acids play a role in increasing platelet reactivity and that the prothrombotic phenotype plays a crucial role in the occurrence of major adverse cardiovascular events. The ongoing increase in cardiovascular diseases’ incidence emphasizes the importance of research linking lipids and platelet function. In particular, the rebound phenomenon that accompanies discontinuation of clopidogrel in patients receiving dual antiplatelet therapy has been associated with changes in the lipid profile. Our many years of research underline the importance of reduced HDL values for the risk of such a rebound effect and the occurrence of thromboembolic events. Lipids are otherwise a heterogeneous group of molecules, and their signaling molecules are not deposited but formed “on-demand” in the cell. On the other hand, exosomes transmit lipid signals between cells, and the profile of such changes can be monitored by lipidomics. Changes in the lipid profile are organ-specific and may indicate new drug action targets. PB - MDPI T2 - International Journal of Molecular Sciences T1 - Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives VL - 22 IS - 6 SP - 3180 DO - 10.3390/ijms22063180 ER -
@article{ author = "Đukanović, Nina and Obradović, Slobodan and Zdravković, Marija and Đurašević, Siniša and Stojković, Maja and Jasnić, Nebojša and Popović-Đorđević, Jelena and Todorović, Zoran B. and Tosti, Tomislav", year = "2021", abstract = "Lipids play an essential role in platelet functions. It is known that polyunsaturated fatty acids play a role in increasing platelet reactivity and that the prothrombotic phenotype plays a crucial role in the occurrence of major adverse cardiovascular events. The ongoing increase in cardiovascular diseases’ incidence emphasizes the importance of research linking lipids and platelet function. In particular, the rebound phenomenon that accompanies discontinuation of clopidogrel in patients receiving dual antiplatelet therapy has been associated with changes in the lipid profile. Our many years of research underline the importance of reduced HDL values for the risk of such a rebound effect and the occurrence of thromboembolic events. Lipids are otherwise a heterogeneous group of molecules, and their signaling molecules are not deposited but formed “on-demand” in the cell. On the other hand, exosomes transmit lipid signals between cells, and the profile of such changes can be monitored by lipidomics. Changes in the lipid profile are organ-specific and may indicate new drug action targets.", publisher = "MDPI", journal = "International Journal of Molecular Sciences", title = "Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives", volume = "22", number = "6", pages = "3180", doi = "10.3390/ijms22063180" }
Đukanović, N., Obradović, S., Zdravković, M., Đurašević, S., Stojković, M., Jasnić, N., Popović-Đorđević, J., Todorović, Z. B.,& Tosti, T.. (2021). Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives. in International Journal of Molecular Sciences MDPI., 22(6), 3180. https://doi.org/10.3390/ijms22063180
Đukanović N, Obradović S, Zdravković M, Đurašević S, Stojković M, Jasnić N, Popović-Đorđević J, Todorović ZB, Tosti T. Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives. in International Journal of Molecular Sciences. 2021;22(6):3180. doi:10.3390/ijms22063180 .
Đukanović, Nina, Obradović, Slobodan, Zdravković, Marija, Đurašević, Siniša, Stojković, Maja, Jasnić, Nebojša, Popović-Đorđević, Jelena, Todorović, Zoran B., Tosti, Tomislav, "Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives" in International Journal of Molecular Sciences, 22, no. 6 (2021):3180, https://doi.org/10.3390/ijms22063180 . .