Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources
Authors
Aničić, Neda
Gašić, Uroš M.

Lu, Feng
Ćirić, Ana

Ivanov, Marija

Jevtić, Bojan
Dimitrijević, Milena
Anđelković, Boban D.

Skorić, Marijana
Nestorović Živković, Jasmina
Mao, Yingle
Liu, Jia
Tang, Chunping

Soković, Marina

Ye, Yang
Mišić, Danijela

Article (Published version)
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Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources—cis,trans-NL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displa...yed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products.
Keywords:
Nepeta / 1 / 5 / 9-epideoxyloganic acid / antibiofilm / antimicrobial activity / immunomodulatory effects / nepetalactoneSource:
Pharmaceuticals, 2021, 14, 5, 414-Publisher:
- MDPI
Funding / projects:
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-200007)
- Grant Nos. 451-03-9/2021-14/ 200007
Note:
- Supplementary material: https://cherry.chem.bg.ac.rs/handle/123456789/4445
Related info:
- Referenced by
https://cherry.chem.bg.ac.rs/handle/123456789/4445
DOI: 10.3390/ph14050414
ISSN: 1424-8247
WoS: 000654389200001
Scopus: 2-s2.0-85105960331
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Aničić, Neda AU - Gašić, Uroš M. AU - Lu, Feng AU - Ćirić, Ana AU - Ivanov, Marija AU - Jevtić, Bojan AU - Dimitrijević, Milena AU - Anđelković, Boban D. AU - Skorić, Marijana AU - Nestorović Živković, Jasmina AU - Mao, Yingle AU - Liu, Jia AU - Tang, Chunping AU - Soković, Marina AU - Ye, Yang AU - Mišić, Danijela PY - 2021 UR - https://www.mdpi.com/1424-8247/14/5/414 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4444 AB - Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources—cis,trans-NL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displayed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products. PB - MDPI T2 - Pharmaceuticals T2 - Pharmaceuticals T1 - Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources VL - 14 IS - 5 SP - 414 DO - 10.3390/ph14050414 ER -
@article{ author = "Aničić, Neda and Gašić, Uroš M. and Lu, Feng and Ćirić, Ana and Ivanov, Marija and Jevtić, Bojan and Dimitrijević, Milena and Anđelković, Boban D. and Skorić, Marijana and Nestorović Živković, Jasmina and Mao, Yingle and Liu, Jia and Tang, Chunping and Soković, Marina and Ye, Yang and Mišić, Danijela", year = "2021", abstract = "Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources—cis,trans-NL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displayed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products.", publisher = "MDPI", journal = "Pharmaceuticals, Pharmaceuticals", title = "Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources", volume = "14", number = "5", pages = "414", doi = "10.3390/ph14050414" }
Aničić, N., Gašić, U. M., Lu, F., Ćirić, A., Ivanov, M., Jevtić, B., Dimitrijević, M., Anđelković, B. D., Skorić, M., Nestorović Živković, J., Mao, Y., Liu, J., Tang, C., Soković, M., Ye, Y.,& Mišić, D.. (2021). Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. in Pharmaceuticals MDPI., 14(5), 414. https://doi.org/10.3390/ph14050414
Aničić N, Gašić UM, Lu F, Ćirić A, Ivanov M, Jevtić B, Dimitrijević M, Anđelković BD, Skorić M, Nestorović Živković J, Mao Y, Liu J, Tang C, Soković M, Ye Y, Mišić D. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. in Pharmaceuticals. 2021;14(5):414. doi:10.3390/ph14050414 .
Aničić, Neda, Gašić, Uroš M., Lu, Feng, Ćirić, Ana, Ivanov, Marija, Jevtić, Bojan, Dimitrijević, Milena, Anđelković, Boban D., Skorić, Marijana, Nestorović Živković, Jasmina, Mao, Yingle, Liu, Jia, Tang, Chunping, Soković, Marina, Ye, Yang, Mišić, Danijela, "Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources" in Pharmaceuticals, 14, no. 5 (2021):414, https://doi.org/10.3390/ph14050414 . .